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Escondida is a state-of-the-art copper mining operation. It is the major copper project of the 1990s and is the largest new investment in the industry - a US$823 million project. It accounts for about six per cent of Chile's total exports, making Escondida the largest private exporting company in Chile.

Jan 1, 1992

By D. W. Loughridge

INTRODUCTION Raising capital in the 1990s is a timely subject. However, many of us thought why should raising capital in the 1990s prove to be unlike it was in the 19805, the 1970s, the 1%0s, or earlier? There are a lot of creative people in banking and in corporate treasury departments. New tools and techniques are continuing to emerge, many of which are discussed in other papers in this book. While we have new financing tools at our disposal, the underlying issue has not changed. Projects and investments must be judged on their own merits. If they cannot be justified by conventional financial analysis, they should not be built. If they can be justified, it is likely that the financing will be available. The challenges faced in raising capital in this decade will persist to the next. The issues of the 1980s -- currency fluctuation, disruptive merger and acquisition activity, commodity price volatility, political risk, and debt crisis -- will all persist in an increasingly international business environment. I will focus on the financing we have just completed for the Escondida Copper Project in Chile. The Escondida financing is structured along the classic project financing model developed in the late 1970s, but it deals with issues of the 1980s and the 1990s. The financing was intriguing, not just because of the technical issues involved, but also the challenge of reaching an agreement in a large and diverse group. Escondida had the one essential feature that made its financing possible. It was commercially very attractive. It would produce at low cost a commodity (copper concentrates) that direct consumers felt would be in tight supply. The project had the direct support not only of its sponsors, but also its customers, and, very importantly, its host government. The non- recourse financing of Escondida would not have been possible without the support of these parties, and without the robust economics that made this effort worthwhile. The issue was more complicated. Operations in all parts of the world entail some political exposure. This project is in Chile, where there was a constitutional requirement that a plebescite be held when the project would be in its early stages. This plebescite would determine the fate of a 15 year old military dictatorship. The project is copper, a commodity generally deemed to be in surplus. Copper has a history of price volatility (whose price has varied from $.58 to $1.53 per pound over the past two years). It is politically sensitive, not only in Chile, but in the United States, Canada and other developed countries. The project is international, with all the problems of dealing with a variety of currencies, a variety of cultures, and a variety of laws and commercial practices. The project is also large and capital intensive, with a total cost of U.S. $1.1 billion. ESCONDIDA PROJECT Escondida, the largest known copper ore body in the world, was discovered in March of 1981, by Utah International in a joint venture with Getty Oil Company. In 1984, both Utah and Getty were involved in ownership changes, Utah being acquired by BHP. A later restructuring of the ownership of Escondida resulted in BHP, as manager, carrying a 60% interest, Rio Tinto-Zinc Corporation (RTZ) 30%, and a consortium of Japanese companies led by Mitsubishi Corporation with 10%. The Japanese consortium is incorporated as JECO (Japan Escondida Corporation). This ownership structure, which spread ownership around the world, was the first tangible step toward managing both the commercial and political risk associated with the project.

Jan 1, 1990

By Wilton Pacheco de Araújo

A siderurgia gera grandes volumes de escória de aciaria como coproduto e precisa incrementar o aproveitamento desse material em novos processos para evitar a disposição em aterros, aumentando a competitividade do setor. Este estudo tem como objetivo caracterizar a escória de aciaria LD da Usiminas em Ipatinga-MG, buscando avaliar o seu potencial para uso como corretivo agrícola e fonte de nutrientes para agricultura. Foram utilizadas técnicas analíticas tradicionais e microscopia para determinar suas principais características. Os resultados mostraram que uma etapa a mais de separação por peneira (2 mm) no processo rotineiro de remoção de metálicos é possível produzir um produto com características químicas e granulométricas estáveis para se constituir um corretivo agrícola comercial. O material apresenta características superiores aos corretivos tradicionais, pois além de corrigir o pH, fornece nutrientes importantes para a agricultura. O processo mais lento de hidratação dos silicatos e de liberação dos nutrientes pode ser interessante para o fornecimento progressivo desses compostos dando longevidade ao corretivo, reduzindo potencialmente o custo de aplicação.

Aug 16, 2017

By Breno Totti Maia, Luiza Siqueira de Magalhães, Vanessa Rodrigues de Medeiros Santos, Inamara Amanda Souza Santos, Brenda Caroline Gurgel, Aline Lima da Silva

O sucesso da utilização do método de reparo/prevenção de refratários de convertedores LD chamado Slag Splashing tem relação com as propriedades físico-químicas da escória, em especial a sua viscosidade. Através de uma simulação termodinâmica feita no software FactSage que tomou como base a equação de Einstein-Roscoe utilizando uma escória de composição representativa de uma escória industrial, junto de uma simulação a frio utilizando soluções representando escórias com variadas frações sólidas, foi possível correlacionar a viscosidade do modelo a frio, avaliando a possibilidade de transposição de resultados desse modelo para a prática industrial em escórias com frações sólidas de até 20%, sendo que acima desse valor um modelo mais assertivo deve ser restabelecido. Por simulação física a frio em um modelo de conversor de escala de 1/10 em relação aos conversores de 340 toneladas da Ternium Brasil, utilizando soluções representativas de escórias industriais com frações sólidas de 10 a 40%, avaliou-se a influência da viscosidade na intensidade na projeção de escória durante o processo do Slag Splashing, deixando claro o efeito da fluidez ou da alta viscosidade na altura, localização e qualidade das projeções.

Oct 1, 2019

By Renan Gurgel Pinho

O objetivo deste trabalho é investigar a esferoidização do aço SAE 1080 e os respectivos efeitos da variação do tempo na microestrutura final e na dureza do material. O aço SAE 1080 foi submetido a recozimento isotérmico, por tempo prolongado, utilizando-se 90, 100 e 120 horas de aquecimento à temperatura de 715ºC. Os resultados mostraram que é possível esferoidizar o aço SAE 1080 nos respectivos tempos escolhidos e perceber aumento da quantidade de esferoiditas, assim como decréscimo na dureza.

Aug 16, 2017

By Garry Biles, Ken Major, Raj Anand

"Prime Resources Group Inc. (Prime) commenced the Eskay Creek Mine operations in 1994 in northern British Columbia. The ore from the underground mine is crushed and shipped to smelters in Japan and Canada. The nominal production rate is 300 tonnes per day.Before commencing the above operations, preliminary evaluations for the high grade gold mine had indicated that an extremely complex metallurgical and chemical process flowsheet would be required to recover the economic metals. Subsequent to the metallurgical testing program, Prime identified markets for the untreated ore and initiated underground mining and ore transportation operations.Prime recently identified lower grade ore zones, which are less economic or uneconomic to mine and ship directly to the smelters. Test programs were initiated to evaluate processes for upgrading the ore to a marketable product. In 1997, Prime will complete the engineering and construction of a 150 tonne per day flotation plant to concentrate the gold and silver values for the NEX and 109 zones. The mine will then, in addition to the direct shipping of the shippable ore, ship concentrate from the millable ore. This paper discusses the development and design of the flotation plant.IntroductionThe Eskay Creek Mine is located in north-western British Columbia approximately 83 km north-west of Stewart, B.C. as shown in the location map Figure 1. Access to the site is provided by a restricted access gravel road from Bob Quinn Lake junction of highway 37, a distance of about 59 km. The work force at the mine is based on a two-week rotation schedule. Employees are flown from as far away as Vancouver to Smithers by commercial airlines and then from Smithers to the Bob Quinn airstrip by local charter. During poor weather conditions, transportation to site is by vans that take about six hours to travel the 450 km road distance."

Jan 1, 1998

By G. Biles

The Eskay Creek Mine, a high-grade gold and silver underground mine in northwestern British Columbia started operations in late 1994. For the first three years of operation, ore was crushed to minus 2 inch; blended to satisfy smelter terms and direct shipped to smelters in Japan and Canada. Before commencing the above operations, preliminary evaluations had indicated that an extremely complex metallurgical facility, requiring a large capital investment, would be required to recover the precious and other economic metals. Subsequently markets for raw ore were identified and underground mining and ore transportation operations, at a nominal production rate of 300 tonnes per day, were commenced. Exploration diamond drilling in 1995 and 1996 discovered additional lower grade mineralized zones, which are less economic or uneconomic as direct shipping ore. Testwork demonstrated that these lower grade zones could be upgraded to marketable concentrates in a simple flotation mill. The mill was built in 1997 and has been in operation since late 1997. The mining rate now has increased to 400 tonnes per day including 250 tonnes per day of the direct shipping ore and ISO tonnes per day of the mill ore. Prime Resources Group Inc. wholly owns the Eskay Creek Mine. Homestake Canada Inc. owns 50.6% of Prime's shares and manages and operates the mine on Prime's behalf. This paper discusses the mining and milling operations as well as ore shipment and smelter contracts' administration.

Jan 1, 1999

By G. Biles, K. Loughran, R. Anand

The Eskay Creek Mine, a high-grade gold and silver underground mine in northwestern British Columbia started operations in late 1994. For the first three years of operation, ore was crushed to minus 2 inch; blended to satisfy smelter terms and direct shipped to smelters in Japan and Canada. Before commencing the above operations, preliminary evaluations had indicated that an extremely complex metallurgical facility, requiring a large capital investment, would be required to recover the precious and other economic metals. Subsequently markets for raw ore were identified and underground mining and ore transportation operations, at a nominal production rate of 300 tonnes per day, were commenced. Exploration diamond drilling in 1995 and 1996 discovered additional lower grade mineralised zones, which are less economic or uneconomic as direct shipping ore. Test work demonstrated that these lower grade zones could be upgraded to marketable concentrates in a simple flotation mill. The mill was built in 1997 and has been in operation since late 1997. The mining rate now has increased to 400 tonnes per day including 250 tonnes per day of the direct shipping ore and 150tonnes per day of the mill ore. Prime Resources Group Inc. wholly owns the Eskay Creek Mine. Homestake Canada Inc. owns 50.6% of Prime’s shares and manages and operates the mine on Prime’s behalf. This paper discusses the mining and milling operations as well as ore shipment and smelter contracts' administration.

Jan 1, 1999

By Garry Biles

The Eskay Creek Mine is a high-grade gold and silver underground mine in northwestern British Columbia. The mine started operations in late1994. For the first three years, ore was crushed to -50 mm(-2 in.), blended to satisfy smelter terms and shipped to smelters in Japan and Canada. Preliminary evaluations indicated that a complex metallurgical facility, requiring a large capital investment, would be required to recover the precious and other economic metals. So markets for raw ore were identified and underground mining and ore transportation operations began at a production rate of 300 t/d (330stpd).

Jan 1, 2000

By P Crorkan

Within the framework in which future exploitations for Codelco-Chile Divisi=n El Teniente are situated, regarding the deepening of its reserves and the geotechnical problems that affect their recovery, it becomes strategic to evolve with new variants, which make deep mining possible. Codelco ChileÆs Divisi=n El Teniente is progressing within its long-term planning the exploitation of a sector called Esmeralda, which includes its removal through the gravitational caving method (panel caving). It is planned to use pre-caving, which basically consists of developing and undermining the undercut level, without having developed the infrastructure of the production and transport levels. This is carried out in order to achieve a better redistribution of the stresses, thus obtaining higher quality in the infrastructure development of these levels as well as less risk. The extraction reserves for this area, estimated through the opportunity cost selection criteria, were determined at 348 million tons with an average grade of 1.014 per cent Cu. The project carried out geological and geotechnical studies in order to prevent the geomechanical risks of the sector to be exploited, which is a site conformed totally by primary ore. Lithologically, it occurs mainly in Andesite, located at the western limit by Brecha Braden Pipe. There are also varieties of porphyries and hydrothermal breaches of anhydrite. The Esmeralda Mine production program will increase from 4000 tpd (average) in 1998 to its 45 000 tpd rate of production estimated for the year 2005. The approved investment for the period 1995 to 1999 is $US 150 million, out of a total $US 213 million for the project. At feasibility study level and before the project, it showed a Net Present Value of $US 342 million, an Internal Rate of Return of 37 per cent and an IVAN indicator of 2.3 for a ten per cent discount rate and a copper price of 100 US cents/lb.

Jan 1, 2000

By Peter Woodall, Paul Telford, Pengfu Tan

"Arsenic enters the Mount Isa copper circuit in the form of arsenic rich minerals in concentrates from both the Mount Isa and Ernest Henry copper mines. Arsenic is a volatile metal, and will partition in the copper smelter between smelter off gases, slag and anode. Most of the volatile arsenic will report to Isasmelt Electrostatic Precipitator (ESP) or Waste Heat Boiler dusts where it will form a re-circulating load within the smelter. ESP dust is produced at a rate of 15,000 - 20,000 t/y and is currently removed from the precipitator and leached in the new ESP Dust Recovery Plant to separate copper and arsenic from the ESP dust. This paper describes the laboratory test works of ESP dust leaching, neutralisation and cementation processes. The planttrial, commissioning and operation have been presented as well.1. IntroductionThe flue dusts generated in the process of copper smelting contain appreciable amounts of copper and other valuable metals including precious metals. These flue dusts also contain appreciable amounts of arsenic trioxide where arsenic occurs in the ore body. The copper smelters processing concentrates generate residuals, such as ESP dust, containing arsenic trioxide. ESP dust contains impurities such as arsenic and bismuth which are harmful to the copper refining process if they report to anode. These impurities are fumed off in the smelting process and report to the dust as arsenic and bismuth oxides.The content of arsenic in the feed of Mount Isa copper smelter is about 0.1 % to 0.4%. Arsenic is a volatile metal, and will partition in the copper smelter between off gases and anode. Most of the volatile arsenic reports to Electrostatic Precipitator (ESP) and Waste Heat Boiler dusts where it will form a re-circulating load within Mount Isa Copper Smelter. Unless arsenic is bled from the smelter circuit, it will build up to a point where both anode quality and smelter hygiene are adversely impacted."

Jan 1, 2011

By T. Marcher, C. Mathiesen, M. Allende, S. Bauer

"A unique pumped hydro storage facility using the ocean as a lower reservoir, combined with solar PV to create consistent, clean power will be presented: the Espejo de Tarapacá Project is comprised of a 300 MW seawater pumped storage hydroelectric plant using the Pacific Ocean as its lower reservoir and an existing natural concavity at the desert as its upper reservoir. The plant site is located in Chile’s northern coast 90 km south of Iquique. The site is characterized by a rocky shoreline and about 600 m of flat terrain moving inland, with an abundance of rock outcrops, after which there is a steep 700 m cliff. The power house and all waterways will be underground. The main focus is to present the rocks being expected in the underground works. As one of the actual most tectonically active regions of the world the seismic activity is particularly relevant and will be outlined in the presentation. INTRODUCTION Valhalla Energy is an independent Chilean-owned power development company. It focuses on the development, ownership and operation of renewable power projects. Valhalla was founded in 2011 with the goal of developing Chile’s natural renewable energy resources and strategically diversifies the country’s energy matrix away from an overdependence on imported fossil fuels. Valhalla began developing pumped storage hydro projects to provide scalable, clean, competitive, and reliable electricity by combining Chile’s superior solar resources with the country’s unique and extensive coastline suitable for storage.The capacity for renewable energy supply is driven by two distinct and unique natural characteristics found in northern Chile: (1) the abundant and reliable solar irradiation in the Atacama Desert and (2) a coastal site that benefits from a steep cliff and a natural concavity both within a relatively small land mass (see Figure 1). There are several potential sites in the northern part of the country that can be developed. The “Espejo de Tarapacá Project” is the first one to be built and subject of the present paper."

Jan 1, 2016

By José Héctor Figueroa Paredes

La industria del procesamiento de minerales tiene problemas respecto a la disponibilidad de agua para sus operaciones -en tanto la escasez del recurso hídrico plantea incorporar en los procesos productivos alternativas de procesamiento orientados a optimizar el consumo de agua. En este sentido, Southern Copper Corporation, considera tecnologías de espesamiento de alta densidad a fin de maximizar la recuperación de agua de los relaves de Cuajone, para asegurar los requerimientos de agua para sus proyectos de expansión. Por ello, el presente trabajo señala la factibilidad de recuperar agua de los relaves Cuajone en la Southern Copper Corporation, a través del método de espesamiento de alta densidad que permita el manejo de pulpa densificada, sin la necesidad de formarse una pasta.

Sep 14, 2009

By Andreize Raphaela Costa

O espessamento é o método mais amplamente utilizado para desaguamento na indústria mineral. O objetivo desse trabalho foi verificar a viabilidade de espessamento conjunto de rejeito e lamas, considerando a utilização de sistemas existentes de espessamento, bombeamento e disposição de rejeitos, para reduzir capex em projeto de expansão. A metodologia utilizada nesse trabalho consistiu na realização de ensaios de sedimentação em proveta variando a proporção de rejeito/lamas, dosagem de floculante e a concentração de sólidos na alimentação. Os resultados indicaram que o espessamento conjunto reduz a área unitária e aumenta a concentração de sólidos no underflow (UF) do espessador.

Aug 1, 2018

By Thokozani Lehae Hanes Malinga

O complexo Minas-Rio da Anglo American iniciou suas operações em agosto de 2014. A usina de tratamento produziu, em 2016, cerca de 15,5 milhões de toneladas secas de concentrado. O minério, explorado no município de Conceição do Mato Dentro (MG), passa pelas etapas de cominuição, classificação, concentração e separação sólido-líquido antes de ser bombeado por 529 km até o município de São João da Barra (RJ), onde é filtrado, estocado e embarcado para exportação. A lama e o rejeito da flotação são enviados para um espessador de 90 metros de diâmetro. Testes de sedimentação em bancada mostraram o efeito positivo da sedimentação dessa mistura de lamas e rejeito. A lama, composta predominantemente por partículas finas de hematita e argilo minerais, se adere a ao quartzo do rejeito, que possui maior diâmetro. Apesar dessa mistura aumentar a velocidade de sedimentação, ela propicia a formação de uma espuma com elevada estabilidade, devido a presença de finos da deslamagem e espumante da flotação. Foram feitos testes de bancada objetivando-se avaliar o efeito da retirada do rejeito da alimentação do espessador. A partir dos resultados foram traçados cenários com diferentes participações desse material e suas implicações no processo de sedimentação foram estimados.

Oct 30, 2017

By Song (Bruce) Li

This paper presents a three-tier web-based GIS application that uses Java Server Page (JSP), Java Servlet and relational database to manage performance monitoring and reporting in the oil sands mining industry. It is a real-time Earth Structure Performance Monitoring System (ESPMS), which allows the user to record and store instrumentation monitoring readings as well as technical observations and instrumentation installation documentations into a complete relational database. The ESPMS introduces the advantages of precise field record keeping, due diligence, security, consistency and completeness while at the same time simplifying the task of reporting. ESPMS combines web-based Geographic Information System (GIS) mapping and data management to facilitate the collection, organization, retrieval, reporting and communication of the vast amounts of monitoring data related to mining and tailings engineering associated with site investigation and construction information. ESPMS utilizes web-based GIS technology to incorporate referenced aerial photographs, Energy, Mines and Resources (EMR) maps or AutoCAD drawings as a base map for the monitoring site. It dynamically creates and administers all instrumentation monitoring locations and reading frequencies. It enables the user to collect and manage the data associated with an unlimited number of reading events. It provides the designer with real-time monitoring data (what, why, when, how), thereby allowing them to make early adjustments to design protocols or procedures, or to take remedial action(s) regarding the subject earth structure under construction or after completion. It provides more cost-effective reporting and data sharing through the Internet. It improves security on data entry and eliminates unauthorized data changes. It allows better integration of graphics and illustrations with numerical data files. It is capable of managing the continually expanding workload resulting from new and larger structures in the oil sands or other mineral mining industries. The ESPMS facilitates easier data gathering for preparation of as-built and after-built or regulatory reports, etc. It enables quick location of the interested instruments and summarization of the performance of the instruments. It enables one to visualize performance data and QA/QC construction test results spatially on any given cross-section. Data can be exported to MS Excel for detailed analysis and to evaluate the stability of the earth structures.

May 1, 2004

By Lucas Xavier Soares de Souza

No contexto de eficiência energética nos setores automobilístico e aeronáutico, a redução de peso em estruturas assume um papel importante. Como alternativa para isso, as espumas metálicas, mais especificamente, as espumas de magnésio e de ligas de magnésio, surgem com grande potencial. Isso se deve, primeiramente, às propriedades desse elemento químico, que é o mais leve entre os metais estruturais. Já a estrutura em forma de espuma aparece como fator capaz de potencializar as propriedades desse elemento. Um dos processos para produção de espumas de magnésio é a metalurgia do pó e uma das etapas desse processo é a compactação dos pós. Busca-se com este trabalho, avaliar a densidade relativa de amostras que foram compactadas a partir da prensagem uniaxial a frio de pós da liga de magnésio AZ91 com hidreto de titânio. Foi verificado que para uma mesma pressão, variando a granulometria da liga AZ91 e a quantidade de hidreto, a variação nas densidades relativas é desprezível. A partir das curvas obtidas nos ensaios de compactação foi possível verificar que na faixa de 130 a 230 MPa ocorreu deformação plástica dos pós de forma gradual e foi possível constatar que a partir de 300MPa não ocorre variação significativa da densidade relativa com o aumento da pressão.

Oct 30, 2017

By Wilfredo A. Lyons

La formación geológica del distrito minero de Castrovirreyna-Huachocolpa está constituída por derrames y piroclásticos de composición andesítica, cuyos volcánicos se encuentran asentados sobre formaciones paleozoicas y mesozoicas altamente plegadas e instruídas por cuerpos ígneos de dimensiones batolíticas. En esta perspectiva, el objeto del texto radica en describir la formación estructural de las minas del distrito e indicar el movimiento relativo de las diversas fracturas del área. El sistema de fracturas se divide en tres grupos: el primero tiene orientación WNW - ESE; el segundo NE - SW, y el tercero, NNE-SSW, los cuales cuentan con características y orientaciones definidas, respectivamente. El origen de las fracturas responde a fuerzas de impresión prientadas NE-SW que formó un sistema de grietas cuyos esfuerzos de cizallamiento se encuentran ubicados a un ángulo menor de 452 a dichas fuerzas y son paralelas a las fuerzas de compresión.

Aug 20, 1965

By N. S. Dalal, X. Shi

"SUMMARYElectron spin resonance (ESR) measurements provide direct evidence for the involvement of the glutathionyl radical, as well as an isolable Cr(V)-glutathione intermediate in the Cr(VI) glutathione redox reactions. These results indicate a new mechanism for the reduction of Cr(VI) by glutathione in relationship to cellular environment and suggest that synergistic reactions of Cr(V) and GS· might be responsible for the (unexpected) increase in the Cr(VI)-induced DNA-strand breaks at high glutathione levels.INTRODUCTIONWhile the reduction of Cr(VI) by glutathione (GSH) is thought to be a critical' step in the pathogenesis of the Cr(VI)-exposure related carcinogenesis1- 4, the exact reduction mechanism is not yet understood. The following reaction steps have been suggested :(A) Initial step:Cr04 2- + GSH - GSCrOa - (1)(B) At high GSH levels:GSCroa- + GSH - Cr( IV) + GSSG (2)(C) At low GSH levels: GSC rO a - - Cr ( V ) + GS ·(3)Thus far, however, in these reactions, the GS· radical has eluded spectroscopic detection, while the evidence for the Cr(V) formation has been reported positives as well as negative2·. Her~ we present spin-trap ESR evidence for the formation of the GS· radical, and a definitive ESR detection of an isolable cr(V)-GSH intermediate in Cr(VI)-GSH reactions.MATERIALS. AND METHODSESR spectra were obtained at X-band (-9.7 GHz) using a Bruker ER200D ESR spectrometer. The magnetic field was calibrated with a self-tracking NMR Gaussmeter (Bruker, Model ER035M) and the microwave frequency was measured with a Hewlett-Packard (Model 5340A) frequency counter. The spin probes, a-(4-pyridyl-1-oxide) -N -tert-butylnitrone (4-POBN) and 5,5-dimethyl~1-pyrroline-1-ox1de (DMPO) were purchased from Aldrich, K2Cr201 from Fisher and used without further purification. All experiments were done at room temperature."

Jan 1, 1989

By N. S. Dalal, X. Shi, V. Vallyathan

"Electron spin resonance (ESRJ spectrum of the hydroxyl (· OH) radical spin adduct with .the spin trap 5,5-dimethyl-1-pyrrolintt-N-oxide has been obtained in suspensions of freshly ground quartz particles. The concentration of the spin adduct (and hence of the • OH radicals) increases with the amount of grinding. The dust's potential for the generation of the· OH radicals is maximum when fresh (i.e., immediately after grinding) and decreases to 50% in about a day on storage in air. Studies involving metal chelates .indicate that the • OH radical formation involves mainly the silica surface and H20 rather than the Fenton reaction. The results suggest that hydroxyl radical reaction(s) could be important in the lipid peroxidation and fibrogenicity by quartz dust, particularly .in acute silicosis. INTRODUCTIONIn this paper we report on our electron spin resonance (ESR) detection of the formation of hydroxyl (·OH) radicals in aqueous suspensions of freshly crushed quartz particles. This work was undertaken with a view to find possible clues to the role of free radicals in the pathogenesis of quartz-induced fibrogenicity, commonly known as silicosis. We noted that while silicosis is one of the major health hazards in coal and mineral industries, the mechanism by which the quartz particles exert their toxic action on cells and the process(es) by which these actions progress to fibrogenesis are still poorly ·understood (Reiser and Last, 1979; Singh and .Rahman, 1987). It is generally thought, nevertheless, that the action of quartz particles on the biological membranes is the starting point of the silicotic process (Parazzi et - al., 1968). A possible clue to the mechanism of the membrane damage by quartz particles, in terms of the role of oxygenated free radicals, is suggested by the following observations. A suspension of quartz particles in contact with alveolar macrophages has been reported (Gabor et al., 1975; Koike et al., 1982) to initiate an enhancement of lipid peroxidation, defined broadly as the oxidative deterioration of polyunsaturated components of lipids. Hydroxyl (· OH) radicals are known to be capable of peroxidation by abstracting hydrogen atoms from cell-membrane lipids (Halliwell and Gutteridge, 1985) and of initiating lipid peroxidation in lysosomal membranes. (Fong et al., 1973). Arong other lines, it is known that exposure of cell membranes, fatty acids, and unsaturated food oils to ionizing radiation, which generates· OH radicals, causes rapid peroxidation (Halliwell and Gutteridge, 1985). Thus • OH radicals (and also other oxygenated species such as Oi, 10 2, and H20 2) might be expected to play a role in the toxicity of quartz. Earlier studies of the aqueous chemistry of quartz suspensions have reported detection of H2O 2 (Kalbanev et al., 1980), implicating the formation of ·OH radicals as transient species. However, we are not aware of any report of the detection of • OH radicals in quartz reactions, and thus the present study was undertaken. Since it-is known that, because of their high reactivity (hence short lifetime) in aqueous media, the • OH radicals cannot be detected via ESR directly (Finkelstein et al., 1980; Buettner, 1982) we have used .ESR combined with the spin-trap methodology (Finkelstein et al., 1980) for studying the· OH formation. The results show that· OH radicals are indeed formed in aqueous suspensions of freshly ground quartz; thus pointing to ·a possible new clue to the cytotoxicity of freshly formed quartz particles and thereby to silica fibrogenicity."

Jan 1, 1988