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By M. Kellner

Due to continuously growing resource demands and increasing requirements for sustainability, safety and environmental protection on the other hand, the mining industry is being subjected to these additional requirements. Over the past few decades progress has been made in all topics. In 1987, the United Nations published the following in the Brundtland Report: ?development that meets the needs of the present without compromising the ability of future generations to meet their own needs.?[5] The term ?Blue Mining? means to work sustainably, economically, ecologically, and efficiently while also improving ergonomics, for example by increasing automation. An example of how mining can actively be involved in energy management will be shown. Initial evaluations of underground cavitites were done for purpose of energy storage. The planning and construction of underground pump storage plants both in active and inactive mining operations was also investigated.

Aug 1, 2013

By Hans D. Gougar

To meet an increasing demand for minerals, mining operations are moving to ever more remote regions. The lack of a local energy supply and infrastructure, coupled with social and regulatory demands for lowered environmental impact of mining operations, presents an opportunity for a seemingly unlikely competitor ? a nuclear power plant. The Modular Pebble Bed Reactor concept, currently in various stages of research and development around the world, offers a high degree of reliability and safety with minimal consequences for the local or global environment. The passive safety features of this design eliminate the need for the extensive active safety systems that add significantly to the cost of current water-cooled reactors. With the MPBR, as with all nuclear plants, there are no appreciable quantities of waste products released to the environment during normal operations. In contrast with conventional reactor designs, the MPBR would also remain radiologically safe even under the most severe abnormal circumstances. The key to the design is the fuel element. Enriched uranium microspheres are coated with various layers of pyrolytic carbons and silicon carbide to form a highly-temperature resistant particle that effectively retains all fission products. These particles are mixed with graphite and formed into 6 cm pebbles. A randomly packed vessel of such pebbles forms the reactor core through which helium is circulated as a coolant. Computer models and tests performed on actual pebble bed reactors confirm that fuel failure temperatures are not reached even during the most severe conceivable loss of coolant accident. The reactor drives a gas turbine cycle with resulting efficiencies as high as 48%, comparable to natural gas-fired units. The low price of uranium fuel and low maintenance requirements translates into competitive operating costs. However, high capital costs prevent the MPBR from competing with natural gas in most markets. In remote applications where no fossil supplies are readily available, the playing field is more level. This paper summarizes the features of two of the more promising candidates for remote applications and discusses the strengths of the MPBR from the perspectives of fuel supply and environmental impact.

May 1, 2002

By J. W. Matousek

Since the late 1800s, copper-nickel ores have been mined and smelted in the Sudbury area. The Canadian Copper Company, the Copper Cliff ancestor of Inco Limited, commenced operations with a blast furnace smelter in 1888. Coal-fired reverberatory furnaces were added in 1911 and multihearth roasters in 1914. The blast and reverberatory furnaces smelted, respectively, coppernickel ores and ore fines until 1930, when a milling process and plant began operating to concentrate and separate the minerals of these two metals. Two reasons for this delay were: (1) the availability of high grade ores suitable for direct smelting; and (2) the difficulties in making the copper-nickel separation. The Mond Nickel Company, however, practiced flotation at its Coniston Smelter site from 1914 to 1930. A bulk concentrate containing six per cent copper and five per cent nickel was recovered from ore of 1.6 per cent each of copper and nickel. Gravity (table) and magnetic concentrates were also produced. Inco Limited (then The International Nickel Company) began laboratory-scale flotation tests on its ores in 1918. This work led, ultimately (in 1930), to the construction of the 7500 tonne-per-day Copper Cliff Mill, designed to recover separate copper and nickel concentrates. Its capacity was expanded to 11000 tpd in 1936, to 18 000 in 1940, and to 27 000 in 1942. Since 1971 it has operated to process only the bulk flotation products from other mills to yield individual nickel and copper concentrates.

Jan 1, 1999

By C. Zangerl, W. Fellin, M. Holzmann, B. Hofer, S. Perzlmaier

"Four deep-seated rockslide systems were investigated and are under surveillance by TIWAG (Tyrolean hydro-electric Company) since the mid-1960s after impoundment of Gepatsch reservoir began. These rockslide systems consist of several individual sliding masses (slabs) which show variable activity from zero to a few centimetres per year. The focus in this paper will be on the findings for the transient deformation behaviour of the Hochmais slab which is part of the “Hochmais-Atemkopf” rockslide system.The rock mass has slid over moraine deposits in the last post-glacial period and was in equilibrium (or slow to extremely slow moving, respectively) until the filling of the reservoir began. During the initial reservoir filling in summer 1964 considerable movements had been observed over a length of 1000 m accompanied with an activation of the Hochmais slab. Geological investigations, additional surface and subsurface measurement showed that the sliding mass is characterized by an en bloc movement and the deformation accumulates within a several metre thick shear zone located within the moraine. In contrast to the deformation characteristics for the first impoundment process (1964 – 1966) where the magnitude of deformation occurred during impoundment, the maximum amount of deformation since 1967 occurs during the drawdown of the reservoir. Based on long term measurement it can be shown that the magnitude of deformations per year correlates with the minimum storage level in the reservoir. Other external influences such as precipitation and snowmelt have no observable impact on the deformation characteristic of the landslide. On the basis of long-term data series it was possible to determine the factors of influence and to elaborate a conceptual mechanical model which describes the transient deformation behaviour of the Hochmais slab induced by the drawdown of the reservoir. The mechanical model considers the reduction of uplift forces in the highly fractured and permeable rock slab during drawdown as well as increasing seepage forces in the less permeable moraine material."

Jan 1, 2015

By Y. Mitani, H. Ikemi, K. Kitamura, H. Honda

"Instead of carbon capture and geological storage (CCS) that does not rely on structural aquifers, injecting carbon dioxide into sedimentary rock deep underground has been considered. For advection velocity of the fluid is slow, the permeability of sedimentary rock deep underground is low. In order to perform the CCS on the low permeable sedimentary rock, it is necessary to clarify the behavior of long term storage properties of carbon dioxide (CO2).In this study, the permeability and storativity of CO2 injected into low permeable rock has been evaluated. The injection of supercritical CO2 has been conducted on the specimen of Ainoura sandstone (unit weight: 2.39 g/cm3, porosity: 11.9 %) saturated with water by using flow pump method. The experiment has been set up to reproduce the similar condition of deep underground reservoir under 20 MPa confining pressure, 10 MPa pore pressure, 35°C temperature and 3 µl/min CO2 injection rate. In order to prevent an increase in pore pressure, the boundary condition on the outlet side of specimen has been kept a constant pressure.As a result, it has been possible to observe step by step the change of the differential pressure between both ends of specimen. Furthermore, the relative permeability and specific storage of rock under supercritical CO2 injection has been examined by the theoretical analysis of flow pump permeability test incorporating Darcy’s law for two-phase flow. It is observed that CO2 has been transmitted gradually while CO2 stored in the rock. It is also clarified that residual water has existed in specimen after showing the constant differential pressure in the end of the experiment. Using the results of the experiment, 3D core-scale flow-simulation by using TOUGH2 has been conducted due to confirm the flow of fluid and CO2 distribution in the specimen. From the experimental results and analytical solution to them, permeability and storativity are identified, and simulation results support the validity of the experimental results."

Jan 1, 2015

By Roger St. C. Smart, Paul Weber, Joan E. Thomas, William M. Skinner, Warwick Stewart, Stuart Miller

For mine sites affected by acid rock drainage (ARD) or with a potential future ARD issue, the prime consideration is not only the classification of different waste rock as potentially acid forming or non acid forming but also the peak acid (and metal) release rates and expected ARD duration during which effective ARD management and acid neutralisation capacity (ANC) are required. Methods for assessment of this ANC (e.g., Sobek tests) are already available but can be unreliable in ARD containing significant proportions of framboidal pyrite or iron carbonates. The measurement of negative ANC values and the release of S to solution showed that significant sulfide oxidation may occur prior to and during testing in samples containing reactive (particularly framboidal) pyrite resulting in serious underestimation of the original ANC. A simple methodology with dissolution in Ar-purged water before ANC testing, removing ferrous salts, and sulfate assay after ANC testing corrects these effects. Results also showed that a significant lag period (up to 432 h) may be needed for complete hydrolysis of Fe associated with the standard Sobek ANC testing of, for instance, siderite. Hence, the ANC of iron carbonates is usually significantly overestimated. By filtering and the addition of H202 until there was no subsequent pH drop (due to Fe hydrolysis reactions), followed by back titration to pH 7.0, the ANC for siderite was similar to the ANC determined after 432 h lag by the Modified Sobek ANC test and to the mineralogical carbonate ANCcarb determined by calculation based on electron probe micro-analysis. A chemical ANC calculation, based on neutralising cations released to solution, has provided a method to quantify the short-term ANC of carbonates and silicates in simple mixed mineral assemblages and waste rock samples. Results showed that silicate ANC can be more important in short-term neutralisation than carbonate ANC in low carbonate samples. In the longer-term, decreasing sulfate and metal loads with increasing pH values suggests that eventually sulfide acidity generation rates will match the longer-term inherent acid neutralisation rates of the sample derived from silicates. A kinetic ANC measurement for silicates, after steady state dissolution is reached, that indicates the number of hydrogen ions neutralised/m2/yr has been developed. These values can be used in estimates of the net acid production profile from wastes with low (and decreasing) pyrite content after the short-term ANC is exhausted.

Jan 1, 2004

By Yves Pépin, Sylvain Lefebvre, Dimitrios Filippou, Guillaume Hudon

"Titanium dioxide pigment plants using the so-called “chloride process” produce considerable amounts of chloride waste, which contains predominantly iron chloride. In most cases, this waste is dissolved in a weak hydrochloric acid solution and then neutralised. The metal content of the waste is dumped as hydroxide sludge, while its chloride content is lost in an effluent.Rio Tinto Iron & Titanium has developed a new proprietary process whereby pure metallic iron and chlorine gas are recovered from chloride waste by electrolysis. This process uses a two compartment cell separated by an anion exchange membrane to prevent iron cycling between its trivalent and divalent valence. The cathode is made of titanium Grade 7, while the anode is a dimensionally stable one of the type “metal–mixed metal oxide” (MMO) for the evolution of chlorine gas. The catholyte is concentrated and pH-adjusted iron-rich chloride solution originating from chloride waste. The anolyte is recirculating solution containing alkali or alkali earth chlorides such as MgCl2, NaCl, etc. Current efficiencies above 90% can be achieved at temperatures about 80°C using catholyte solutions almost saturated in iron chloride and other chlorides.In this paper, we discuss the details of this process, and how this could be integrated within a chloride pigment plant for the treatment of chloride wastes."

Jan 1, 2016

By Y. Hanada

Electrorefining at higher current density is desirable due to the increase in productivity attained without expanding the plant size. However, increasing the current density in common commercial practice causes problems such as anode passivation, dendritic deposition, cathode impurities and energy consumption. In general, agitation of the electrolyte is effective in suppressing these problems. To apply the agitation to commercial practice effectively, the method of agitation is important. One possible method is agitation by gas injection. In this study, fluid motion characteristics with gas injection between electrodes were investigated using a water model. Flow patterns were observed and fluid velocity was measured using a particle tracking method. It was found that the time-averaged velocity near the electrode walls was of the order of 0.1 m/s in the conditions. The flow was highly turbulent. The turbulent component of velocity was the same order as the time-averaged velocity. The mass transfer coefficient between the wall and fluid doubled when the effect of turbulent intensity was taken into account. The effects of gas injection on the electrolysis behaviour at high current density were discussed in terms of the mass transfer. It is suggested that gas injection could suppress the problems at high current density.

Jan 1, 2007

"NI 43-101 is a rule that governs how issuers disclose scientific and technical information about mineral projects to the public in Canada. The disclosure standards apply to oral statements as well as written documents and websites. NI 43-101 does not apply to disclosure concerning petroleum, natural gas, bituminous sands or shales, groundwater, or coal be methane. NI 43-101 first came into force on Feb. 1, 2001 and was revised in December 30, 2005. As a “National Instrument”, the law has been passed in each provincial and territorial legislature across Canada.“PART 1 DEFINITIONS AND INTERPRETATION 1.1 Definitions - In this Instrument “adjacent property” means a property(a) in which the issuer does not have an interest;(b) that has a boundary reasonablyproximate to the propertybeing reported on; and (c) that has geological characteristics similar to those of the property being reported on; “data verification” means the process of confirming that data has been generated withproper procedures, has been accurately transcribed from the original source and is suitable to be used; “development property” means a property that is being prepared for mineral production and for which economic viability has been demonstrated by a feasibility study; “disclosure” means any oralstatement orwritten disclosure made by oron behalf of an issuer and intended to be, orreasonablylikely to be, made available to the public in a jurisdiction of Canada, whether or not filed under securitieslegislation, but does not include written disclosure that is made available to the public only by reason of having been filed with a government or agencyof government pursuant to a requirement of lawother than securities legislation; “early stage exploration property” means a property that has(a) no current mineral resources or mineral reserves defined; and (b) no drilling or trenching proposed; in a technical report being filed in a local jurisdiction; “exploration information” means geological, geophysical, geochemical, sampling, drilling, trenching, analytical testing,assaying, mineralogical, metallurgical and other similar information concerning a particular property that is derived fromactivities undertaken to locate, investigate, define or delineate a mineral prospect or mineral deposit; “feasibility study” means a comprehensive studyof a mineral deposit in which all geological, engineering, legal,operating, economic, social, environmental and other relevant factors are considered in sufficient detail that it could reasonably serve as the basis for a final decision by a financial institution to finance the development of the deposit for mineral production; “historical estimate” means an estimate of mineral resources or mineral reserves prepared prior to February 1, 2001;“IMMM Reporting Code” means the classification system and definitions of mineral resources and mineral reservesapproved by The Institution of Materials, Minerals, and Mining in the United Kingdom, as amended; “JORC Code”means the Australasian Code for Reporting of Mineral Resources and Ore Reserves prepared by the Joint Ore Reserves Committee of the Australasian Institute of Mining and Metallurgy, Australian Institute ofGeoscientists and Mineral Council of Australia, as amended; “mineral project” means any exploration, development or production activity, including a royalty interest or similarinterest in these activities, in respect of diamonds, natural solid inorganic material, or natural solid fossilized organic material including base and precious metals, coal, and industrial minerals;"

Jan 1, 2003

By J. R. Meyer, P. L. Dean

"The Department of Mines and Energy is at present investigating the dimension-stone potential of the Nain anorthosite complex. These rocks are known to host occurrences of labradorite, a semiprecious gemstone known for its beautiful play of colours (chatoyance). Test blocks that contain 5% to 18% chatoyant labradorite were extracted from three prospects south of Nain. These have been slabbed and polished for further evaluation.Second-grade labradorite stockpiled around the Grenfell quarry on Tabor Island is also being evaluated as a potential source of aggregate for use in terrazzo tiles, precast concrete and epoxy-backed wall panels.IntroductionThe Nain anorthosite complex consists of approximately 10000 km2 of anorthosite and related basic rocks , which are well exposed along the coast of Northern Labrador (Fig. 1) (Emslie et al., 1972). These rocks have been known for centuries to host deposits of gem-quality labradorite. The chatoyant nature (i.e. the play of colours or labradorescence) of this semiprecious feldspar has been utilized mostly in the making of jewelry and other polished, handcrafted products. In the early sixties, Brinex Limited (now Brinco Limited) attempted larger scale commercial exploitation of labradorite, including use 'as building stone and in polished precast concrete for facings on buildings' (Brummer, 1984). After six years of work, which included market studies, Brinex decided that, at that time, the demand did not warrant further production.In recent years, there has been a dramatic increase in the markets for dimension-stone. In the period from 1980 to 1985, the demand in the United States for granite, much of which is imported, has increased 1735070 (Marble Institute of America, 1986). The dimension-stone industry's remarkable growth rate has, in part, resulted from new technology that makes it easier and faster to quarry and cut stone. This has allowed natural storie to compete with other building materials. Now, it is not only used for exterior cladding and walkways, but also on interior walls and floors, and in home and office furnishings, such as countertops for kitchens and bathrooms, table and desk tops, stairways, window sills, and fireplaces."

Jan 1, 1988

By J. R. Meyer, P. L. Dean

"The Department of Mines and Energy is at present investigating the dimension-stone potential of the Nain anorthosite complex. These rocks are known to host occurrences of labradorite, a semiprecious gemstone known for its beautiful play of colours (chatoyance). Test blocks that contain 5% to 18% chatoyant labradorite were extracted from three prospects south of Nain. These have been slabbed and polished for further evaluation.Second-grade labradorite stockpiled around the Grenfell quarry on Tabor Island is also being evaluated as a potential source of aggregate for use in terrazzo tiles, precast concrete and epoxy-backed wall panels.IntroductionThe Nain anorthosite complex consists of approximately 10000 km2 of anorthosite and related basic rocks , which are well exposed along the coast of Northern Labrador (Fig. 1) (Emslie et al., 1972). These rocks have been known for centuries to host deposits of gem-quality labradorite. The chatoyant nature (i.e. the play of colours or labradorescence) of this semiprecious feldspar has been utilized mostly in the making of jewelry and other polished, handcrafted products. In the early sixties, Brinex Limited (now Brinco Limited) attempted larger scale commercial exploitation of labradorite, including use 'as building stone and in polished precast concrete for facings on buildings' (Brummer, 1984). After six years of work, which included market studies, Brinex decided that, at that time, the demand did not warrant further production.In recent years, there has been a dramatic increase in the markets for dimension-stone. In the period from 1980 to 1985, the demand in the United States for granite, much of which is imported, has increased 1735070 (Marble Institute of America, 1986). The dimension-stone industry's remarkable growth rate has, in part, resulted from new technology that makes it easier and faster to quarry and cut stone. This has allowed natural storie to compete with other building materials. Now, it is not only used for exterior cladding and walkways, but also on interior walls and floors, and in home and office furnishings, such as countertops for kitchens and bathrooms, table and desk tops, stairways, window sills, and fireplaces."

Jan 1, 1988

By C. O. Aksoy

Operating the underground marble quarries effectively, it is important to evaluate the deposit blocks economically which are affected by the suitability of the topography and configuration of bedding. The joint sets within the deposit and the spacing between these discontinuties are also of great importance. In this study, the marble deposits that could be geomechanically eligible for underground excavation have been selected throughout Turkey and these selected reserves have been classified accordingly by Q-Rating System. These classified marble deposits that forms groups of 1,2, and 3 (groups were determined by evaluating the O-rating, topography, quarry situation, cracks, joints etc.) are convenient for this type of production. Nevertheless, when the auxiliary factors (topography, location, production method etc.) regarding the deposit have also been investigated, the most convenient sub-group of deposits (Afyon Tiger Skin, Burdur Beige, Diyarbakir Pink and Mugla White) have emerged. The sizing of the pillars have been performed utilising Bieniawski?s stress profile. The LAMODEL software, developed by National Institute for Occupational Safety and Health (NIOSH), USA and run under the laminated displacement discontinuity method, has been used to size the pillars. This work brings in a novel opportunity to Turkey, in which no underground marble quarry has been attempted up-to-date similar to its several examples in Italy, USA, etc. This study serves as a reference for the marble operators and for the pioneering application of laminated displacement discontinuity method in hard rocks.

Apr 1, 2005

By R. De Ruiter

"In times when mines are emphasizing cost reductions, a properly rebuilt shall conveyance can be more cost-effective than building a new unit. Awareness of the safety aspects of conveyance design along with proper maintenance playa large part in reducing operating costs. A knowledgeable operator can maintain a high level of safety and significantly lengthen the service life of a conveyance. Such an operator is also in a better position to determine when a major overhaul is necessary.After the decision has been made to rebuild, operators must decide who will do the overhaul. Whether the work is to be done in-house or contracted out, the goal is to achieve a conveyance recertified to ""as new"" condition. By dealing with conveyance rebuilds as an engineered product, operators can be certain they are getting a top quality product for their money.This paper deals with the engineering aspects of conveyance rebuilds. Actual examples of typical problems are discussed and corrective action outlined. Design considerations such as proper material selection, component fatigue due to cyclic loading, effects of stress concentrations and corrosion are all part of the initial design considerations that must carryover into the rebuild process. All too often equipment overhauls are done by people who are not experienced in conveyance design.As a manufacturer of mining equipment, Wabi has gained expertise over the past 70 years. By sharing this knowledge the company hopes to create a safer work environment and help to reduce operating costs."

Jan 1, 1994

By L. Sun

In this work, strontium doped lanthanum ferrite (LSF) and their composite cathodes were fabricated by screen printing on yttria-stabilized zirconia (YSZ) electrolytes. Their electrochemical properties were evaluated by using electrochemical impedance spectroscopy and steady-state polarization methods. All the cathodes were screened by comparing their total polarization resistances before and after activation processes at different temperatures. The improved LSF composite cathodes were also screen-printed on YSZ/NiO half cells to fabricate solid oxide fuel cells (SOFCs), which have reached the output power densities of 170 mW/cm2 at 650 °C, 230 mW/cm2 at 700 °C, 304 mW/cm2 at 750 °C and 388 mW/cm2 at 800 °C.

Jan 1, 2005

By L Mariani, G. Mendoza-Suarez

In this investigation, TiH2 powders were coated with copper and nickel by electroless plating to delay hydrogen evolution. Copper-coated samples were found to have a mixed acicular (2D growth) and cauliflower (3D growth) morphology whereas the nickel-coated samples had a cauliflower morphology. Examinations of the coated powder cross-sections revealed that the coating thickness ranges from 0.2 µm to 4 µm. Uncoated areas on the powder surface and coating flakes unattached to TiH2 particles suggest poor adhesion between the coating and the substrate. The phase transformation undergone by the TiH2 during dehydrogenation was studied in samples taken at intermediary points in the heating cycles and examined by XRD. The findings reveal that as the powder is heated from room temperature to 800°C, it changes from TiH1.971 to Tiu and to aTi. Differential Thermal Analysis (DTA) was performed to study the effects of the coatings on the temperature of hydrogen release. It was found that increasing the number of plating iterations, and therefore the thickness of the coating, creates a significant shift in the temperature of gas release.

Jan 1, 2006

By C. A. Rowland

"Plant owners and operators, plant designers and grinding mill manufacturers are giving much attention to the design and manufacture of autogenous and semi-autogenous grinding mills, particularly the mills that have large diameters and draw power up to 10,000 hp and greater. Reliable designs giving long operating lives are required in today 's ore processing plants.This paper reviews bench-scale and pilot-plant testing to determine first if the ore is suitable .to be ground by these methods and then reviews the data obtained from pilot-plant testing that is used to select the mills and the grinding circuit. The paper then discusses the use of the pilot-plant results to design the mills. The most important pilot-plant data used for mill design are power and the amount of ball charge to be used. The mill size selected is a combination of these factors. Pilot-plant data not only establish power requirements, but can be used in the selection of the type of drive, variable speed or fixed speed, and the operating procedure to be followed. This leads into the mill control circuit to be used. The total charge in the mill, the type of drive and mill discharge arrangements are needed in the calculation of stresses and bearing loads. Conclusions reached from pilot-plant work are used to obtain data for process design, and autogenous and semiautogenous mill design should be part of any test program incorporating either or both of these grinding methods."

Jan 1, 1981

By Eugene Sun, Qiang Xu

This presentation will review current applications of composite materials in aircraft design and discuss the challenges involved in maximizing the potential of the composites in aircraft applications.

Jan 1, 2010

By J. Wickens

"Campbell Mine is dedicated to quality management in the form of a Continuous Improvement (CI) Operating Philosophy. This paper discusses that philosophy, why and how it is being implemented in the milling facility, and some of the challenges experienced to date. Examples of mill CI team projects and results are described. This paper describes practical experiences for those who are considering or are in the process of adopting a CI operating Philosophy.INTRODUCTIONCampbell Mine is 100% owned and operated by Placer Dome Canada Ltd. The mine is located in Balmertown, Ontario approximately 300 km northeast of Winnipeg, Manitoba. Campbell Mine has produced over s,000,000 ounces of gold since commencing operation in 1949. The operation is profitable and continues to be a major contributor to the gold production of Placer Dome Inc.At Campbell Mine, the concept of Continuous Improvement (CI) is being implemented to make further improvements to safety, quality, productivity, and subsequently profits. CI is not a ""program"". It is a way of doing business that concentrates on improving the system rather than finding fault and being resigned to the status quo.CI focuses on involving all employees in the decision making process and tapping their expertise to improve every facet of the business. In the past, many solutions were simple ""band-aid"" fixes treating the symptom, only to see the problem resurface again. With CI, solutions endeavour to address the root cause of problems and eliminate them permanently. Another primary goal is to eliminate unilateral decisions that benefit a small group but have a negative effect on the whole system."

Jan 1, 1995

By R. A. Rabnett, G. Paget, Patrick Walsh

"Tumbler Ridge, Canada's newest resource community, has been developed differently than have been other resource communities.Since its conceptualization, emphasis has been placed on the establishment of a traditional municipal government at early a stage as possible.Planning f or the community goes back to 1977. By then, extensive study by provincial agencies had shown a new resource town would be required to exploit north east coal. The Ministry of Municipal Affairs, in conjunction with a consultant named R.A. Rabnett began the extensive Tumbler Ridge conceptual plan.The results of the conceptual plan are evident in the organizational and planning goals of Tumbler Ridge. In every aspect from the election of officials to some financial matters, the town functions as a normal municipality. With the resource companies of the North East Coal Development within its municipal boundaries. Tumbler Ridge has been able to debenture its capital projects against its municipal tax base.The town's ability to function as a normal municipality is enhanced by its control over Crown land it has purchased from the province. This gives it further control over the development of the community and helps in establishing agreements with the resource companies and the provincial government to ensure that housing and service needs are met. While resource company representatives sit on certain municipal committees, their roles are advisory in nature.The community continues to move toward full municipal status and will have a fully elected Council by 1986.BackgroundPlanning for the development of northeast British Columbia coal resources began in 1976 under the aegis of the provincial Cabinet Committee on Coal Development. A series of subcommittees were established including a Townsite/Community Development subcommittee. The Ministry of Municipal Affairs chaired this subcommittee and continued as the lead agency for the provincial settlement planning effort over the period 1976 to 1981."

Jan 1, 1983

By Simon P. Fricker

Gold drugs have been used for the treatment of rheumatoid arthritis since the mid 20th century as disease-modifying antirheumatic drugs (DMARD) class. Methotrexate is often the preferred DMARD, and with the advent of new therapies gold drugs are now used infrequently. Since the introduction of auranofin in 1985 there has been no new clinically approved gold drug. In spite of this apparent lack of progress there has been a great deal of interest in the use of gold compounds for cancer therapy and early promising indications were achieved with a gold phosphine complex [Au(dppe)2]Cl. This compound was not entered for clinical trials, however, due to problems with cardiotoxicity highlighted during pre-clinical toxicology studies. Gold(III) is isoelectronic (d8) with platinum(II) and likewise forms square planar complexes. It is therefore tempting to speculate that such complexes would have similar antitumor activity to cisplatin. In order to stabilise the gold(III) oxidation cycloaurated complexes were synthesised with a single mononegative bidentate ligand, damp, (2-[(dimethylamino)methyl]phenyl), and two monodentate anionic ligands e.g. Cl or acetate. The damp ligand forms part of a five-membered chelate ring. The monodentate ligands are readily hydrolysed and are available for substitution. These compounds had limited anti-tumor activity in in vivo against human tumor xenografts. Mechanistic studies indicated that these compounds had a different mechanism of action to cisplatin. An alternative molecular target for these compounds is biologically important thiol-containing molecules such as the cysteine protease cathepsin B. Modifications were made to the Au(III) damp structure to give compounds with a six-membered chelate ring. These compounds were shown to be inhibitors of cathepsin B. Compounds were also tested for cytotoxicity against a panel of human tumor cell lines. Three compounds were selected for further evaluation against a human colon tumor xenograft. The compounds showed modest anti-tumor activity but with no marked improvement over the parent Au(III)damp complexes. Initial indications are that Au(III) compounds targeted against disease-specific thiol-containing biological molecules have potential as drugs, particularly for cancer. However, further work is required to produce a target-specific drug with a suitable pharmacological activity and toxicity profile.

Oct 1, 2003