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Any Australian who knows of the poverty of the early settlers in the first few years following the arrival of Captain Arthur Phillip with his "first fleet" at Botany Bay must feel proud of the progress that has been made in the 174 years that have elapsed since that momentous occasionGFor all its attractive appearance as reported by Captain Cook and Sir Joseph Banks, the shores of Botany Bay and of Port Jackson proved most ,inhospitable, and the accessible country surrounding them anything but suitable for sustaining the life of the small settlement. It is well known that during the first 15 or 20 years the hardy colonists and un-tfortunate convicts were close to starvation on several occasions and were only saved by the arrival of supply ships, which were dependent on the vagaries of wind and current, and the hazards of the uncharted seas they had to -navigate-.When Australia was little more than a miserable penal settlement, Great Britain was one of the great-powers of the world, and the U,.S.A. was an independent nation with a growing degree of prosperity that even then gave promise of its mighty awakening to become, as it has, a e.olossus of industry and commerce,-and the. leader in living standards of the world to-day.Australia, from such a shaky, and comparatively recent start, has risen to a position in which its living standards rank very high in comparison with those of most of the nations of Europe and America. Exact com-parisons are hard to fix because of the wide variety of factors involved .but the Institute of Pab?Lic Affairs .(Victoria) places Australia fifthin the world, excelled only by the U.S.A., Canada, Sweden and Switzerland. The next best after Australia are the United Kingdom, West Germany and France.How we achieved such a high standard of living is a vast subject for study but some of the economic aspects of our climb from abject poverty to a position of near affluence can readily be identified.

Jan 1, 1962

By Euzebio De Oliveira

ONE of a recent batch of samples from the Serra da Baliza, in the state of Parana, Brazil, contained asphalt and a dark heavy oil; and workmen on the railway from Porto União to Uruguay discovered asphalt, coming from eruptives that outcrop along the Rio de Peixe. The occurrence f asphalt in the triassic eruptives of southern Brazil, however, has been known a long time, according to Dr. Gonzaga de Campos. It is generally believed that the Botacatú sandstone is always a hard vitrified rock, from the metamorphic action f. the overflowing eruptive contacts. In this region, however, the contact metamorphism is almost nil; the sandstone is slightly hardened in a narrow zone about 20 to 30 cm. wide. In many places, the sandstone is so friable as to be easily reduced to sand, which is used-.in, mortar for building in Guara-puava and Palmas. South and west from Porto União,. this bench of sandstone is about. 50 m. thick, and is capped by a heavy bed. f basic eruptives, many of which are amygdaloids. Dr. Geo: P. Merrill, after studying the triassic eruptives collected by the Coal Commission, reached the conclusion that. "All these rocks are of typical basalt-diabases, not in any essential different other than in structure. An interesting mineralogical phase is its paucity in olivine, which in many cases is completely lacking. Professor Hussak, who carefully studied these rocks and their accessory minerals, decided that in the dikes they are granular (diabase) and, that in the lava sheets, porphyritic (augite-porphyrite or melaphyre), and that the latter pass evidently to normal diabases and are always typical of effusive rocks. The examination f many slides from dikes and sheets leads us to adopt the opinion of Professor Hussak; the rocks of the dikes are of ophitic structure, while that of the sheets show a great variety f structure and may vary from almost granular to basaltic. The great paucity in olivine had been noted by Hussak, who classes as melaphyres, the porphyritic triassic rocks in Brazil which contain olivine.

Jan 4, 1921

By J. M. Richards

For most of the 20th century optical petrography has been the primary petrological and mineralogical tool used to characterize coal. The development of quantitative SEM-based techniques, e.g. QEMSCAN®, for coal began only about a decade ago. The application of these techniques for coal lagged behind other commodities, but they are currently being developed with the aim to provide ?one complete analysis? for coal. Quantitative SEM-based techniques are supplemented by quantitative X-ray diffraction (XRD). Recent indications are that these more modern techniques cannot replace the ?standard? petrographic and chemical evaluations, but rather complement them where and when required. The great advantage of quantitative SEM-based techniques is that they are very rapid, with the result that large volumes of samples can be processed on a routine basis. This is ideal for coal type identification, since the results can be used in the creation of ?intelligent? composites. This can lead to the more speedy evaluation of coal deposits by reducing the number of samples on which detailed metallurgical and characterization test work is required, without an increase in the overall statistical error of the resource model. Coal petrography, however, remains important for the prediction of the coking characteristics of certain coals and coal products. As a consequence it is therefore important that any coal laboratory be able to produce data with confidence. This requires strict quality control and assurance protocols that adhere to international standards. Keywords coal petrography, coking strength, scanning electron microscopy, QEMSCAN®.

Nov 1, 2013

By Laszlo Imreh, Pierre Trudel, André C. Tessier

"The Siscoe gold mine is ranked as the fourth largest mine in the history of the Val d' Or mining district with a total production of 27.4 tAufrom1929 to 1949. Most of the gold mineralization occurred in quartz veins, hosted in a small (.69 km2) intrusion of altered quartz gabbro known as the Siscoe stock. The southern contact of the Siscoe stock is crosscut by a major shear zone (the ""K"" zone) trending 295/80 NE and from which gold mineralization was also exploited within the limits of the stock. Field and petrographic observations of the Siscoe stock combined with chemical analyses of major, trace and rare earth elements of the stock and its volcanic host rocks (Dubuisson Formation) suggest that:The Siscoe stock comprises four alteration facies formed from a homogeneous precursor: 1) the actinolite - Mg-chlorite facies, characterized by low FeOt,Na2O andTiO2 , and highAlp3 and MgO; 2) the albite- Fe-chlorite facies, containing high concentrations of FeOt and Nap; 3) the Mg + Fe-chloritefacies, which is transitional between the actinolite- Mg-chlorite and albite- Fe-chloritefacies; 4) the carbonate-chlorite facies, which consists of rocks that were subjected to extreme hydrothermal alteration, is spatially associated with mineralized veins and part of the K-zone. The first three facies are depleted in SiO 2, CaO and Au, and enriched in MgO, relative to fresh rocks of the Siscoe stock and the equivalent rocks of the Dubuisson Formation.Hydrothermal fluids introduced mainly along the K-zone ""channelway"" induced three types of element remobilization, resulting in the various alteration facies: 1) redistribution of elements within the stock from one facies to another (e .g., FeOt, Nap, Ti02 migrated from the actinolite- Mg-chlorite facies to the albite- F e-chlorite and Mg + Fe-chlorite facies); 2) remobilization of elements from the intrusive rocks into veins (e.g ., SiO 2 and CaO ); 3) introduction of elements by hydrothermal fluids in rocks of the Siscoe stock (e .g., Al2O3, MgO, H2O, CO2 and FeOt).The Siscoe stock and the Dubuisson Formation form part of the same tholeiitic suite. Similarly, the Bourlamaque batholith and the Val d'Or Formation belong to a single calc-alkaline suite. In view of this relationship, dissimilarities between the petrochemistry of the Siscoe stock and the Bourlamaque batholith suggest that the two intrusions are not co-magmatic.Finally, gold may have been leached from rocks of the Siscoe stock and remobilized into the quartz-carbonate mineralized veins. In order to account for the total production at the Siscoe mine, approximately 1.2 km3 of the Siscoe stock is thought to have been partially leached of its gold."

Jan 1, 1990

LIST OF CONTENTSAbstractIntroductionSelected Sections of the Broken Hill LodeLocality PlansPetrology1. Zinc Corporation Mine: DDH. 5.98, section 30, No. 26 level2. Zinc Corporation Mine: DDH. 838, section 30, No. 13 level3. Broken Hill Sonth Mine: 60 ft. cont01(r above 1170 ft. level4. Broken Hill South Mine : No. 7 shaft section, 1370 ft. levelOrigin of garnet sandstone5. Barrier Central Pty. Ltd.: DDH. tJ.93, Block 136. North Broken Hill Ltd.: Junction mine, DDH. 602, No. 10 level7. North Broken Hill Ltd.: Jnnction mine, DDH. 588, No. 11 level8. North Broken Hill Ltd.: North mine, DDH. through Southern ore body, 3370 ft. level9. North Broken Hill Ltd.: North mine, Northern ore body above 2300 ft. level(a) Southern end, section 27, 77 ft. above rails(b) Northern end, section 30, 6.9 ft. above rails(c) Miscellaneons samples, sections 27 and 28Relative time of ore depositionSericitizntionStructural significance of sericitizationGCLhnite OrthoclaseApatite GarnetManganese SilicatesAlteration of manganese silicatesRelation of zinc and lead to the silicatesZinc in manganese-bearing silicatesLead in potassium and lime silicates and apatite

Jan 1, 1959

By A. Dogan Paktunc

Abstract - The Mechanic Settlement pluton is a small body of mafic and ultramafic rocks of tholeiitic affinity, occurring in the Late Neoproterozoic volcanosedimentary rocks of the Avalon terrane of the Appalachian Orogen. The lenticular-shaped intrusion is layered and consists of ultramafic and mafic lithologies in at least six cyclic units that are relatively thin or short-lived. The lowermost exposed portion of the intrusion is characterized by the cumulate sequences of olivine and olivineclinopyroxene and display relatively flat rare earth element profiles. In the overlying lithologies, plagioclase is the dominant cumulus phase following olivine in the crystallization sequence. Olivine ranges in composition from Fo73 to Fo85 and plagioclase from An62 to An89. Variations in the compositions of orthopyroxene and clinopyroxene are within Wo0-4En52-87Fs11-45 and Wo39-50En23-50Fs3-19. These mineral compositional variations in part reflect cryptic patterns and correspond to normal fractionation trends in cyclic units. Elevated Pt and Pd concentrations of up to 2.6 ppm occur in ten zones within the central cyclic series in association with both the peridotitic and gabbronoritic rock types. The mineralized zones are about several meters thick and appear to have lateral continuities over several hundred meters, suggesting that they are stratiform. Platinum-group elements (PGE) occur as discrete platinum-group minerals (PGM) including vysotskite, merenskyite, michenerite, sperrylite, stillwaterite, and hollingworthite that are associated with magmatic sulfides composed of pentlandite, pyrrhotite, and chalcopyrite. PGM grains range in size from a few micrometers to well above 20 µm. Sulfur isotope ratios and the Se/S ratios of the mineralized rocks are typically higher than the mantle values. Sulfide saturation probably occurred as a result of assimilation of crustal rocks and magma mixing during emplacement of subsequent pulses of magma. Repetition of the PGE mineralization in rather thin cyclic units suggests that the replenishing magma probably had high PGE levels and was saturated with respect to sulfide during emplacement. Ingression of the replenishing magma into the chamber in a turbulent plume and its mixing with the resident magma was probably responsible for the formation of the PGE mineralizations in the Mechanic Settlement pluton.

Jan 1, 2000

Drill cores from Section 62, New Broken Hill Consolidated Ltd., were used to study the petrology of rocks associated with the zinc lode. The distribution of the rock types in relation to the lode structure was determined. The distribution of the gahnite-bearing rocks was shown to be only partly conformable with the structure.It was concluded that large scale metasomatism was not widespread, that the rocks associated with the lode (except, perhaps, the quartz-gahnite-garnet rocks) were formed by metamorphism of sediments, and that rocks and lode were contemporaneously metamorphosed.INTRODUCTIONThis investigation was undertaken in order to study the rock types associated with the zinc lode of the Broken Hill orebody, and their relationship to the structure of the ore horizons. The work was confined almost entirely to the laboratory, and is therefore limited in its scope. It is hoped, however, that the information gained may throw some new light on the genesis of the lode.Certain inferences which are drawn from this work are at variance with the ideas of a number of earlier workers.In particular, the idea of large scale metasomatism developing many of the rocks associated with the lode, especially those containing manganese, is questioned. On the contrary, the rocks associated with the lode are more simply explained as highly metamorphosed sediments, in some cases modified by water introduced from surrounding rocks into zones of strong folding and faulting. As a corollary, a metamorphicsedimentary origin for the lode material, either as a concentrated sulphide deposit, or somewhat disseminated...

Jan 1, 1961

By P Maillet, A J. Crawford, S M. Eggins

TheFiji Islands are remnants of a once continuous Solomon-Vanuatu-Fiji-Tonga volcanic arc (the Vitiaz arc), located at the boundary between the Indian-Australian and Pacific plates. They record a history of: (i)                  arc volcanism the late Eocene to late Miocene, (ii)                an extensive magmatic response to arc rifting (5.5 - 3.0 Ma) during which volcanism was dominated by shoshonitic to tholeiitic basalts, and as rifting continued, (iii)               a transition from arc to intraplate volcanism.   The Hunter Ridge-Hunter Fracture Zone separates the inactive South Fiji Basin from the actively spreading North Fiji Basin, and has been considered to be a transform zone, almost parallel to the motion vector of the Australian plate. However rocks dredged during the 1993 æAlizeÆ cruise, from along the northern part of the Hunter Ridge are typical arc tholeiites, and therefore demand that subduction has occurred beneath the Hunter Ridge sometime during the last ~5 Ma. The Kadavu Island group, south westernmost Fiji, lies at the north-eastern end of the Hunter Ridge-Hunter Fracture Zone, and possibly results from oblique subduction of South Fiji Basin oceanic crust, which may have accompanied the anticlockwise rotation of Fiji during opening of the North Fiji Basin. These islands consist dominantly of 3.4 - 0.5 Ma old medium-high K andesites and dacites, with many traits typical of subduction-related volcanics, ie predominance of intermediate members (55 - 65% SiO2) no Fe enrichment, TiO2<1%, and negative Nb-Ta anomalies. These features contrast strongly with volcanics from elsewhere in Fiji around this time, where volcanic centres produced Om-like intraplate olivine basalts. The Kadavu Islands become gradually younger to the southwest, and show a significant decrease in K2O with time. The north easternmost islands (Astrolabe islands) containing the oldest rocks (~3 Ma) have shoshonitic affinities and are considered to be of similar age and composition to the youngest shoshonites found elsewhere in Fiji.

Jan 1, 1995

By Shamim A. Dar, & Samsuddin Khan, & K. F. Khan, Mohd Shuaib

The Late Paleocene–Middle Eocene phosphate nodules of Solan District of Himachal Pradesh belong to green facies of Subathu Formation of Sirmur group. Field observations indicate sporadic distribution of phosphatic nodules in the yellow brown to rusty brown, buff-colored bleach shales. Phosphatic nodules are dull earthy to dark grayish in color and break with sharp and conchoidal surfaces. Studies of phosphatic nodules using petrological microscope, X-ray diffractometry, and scanning electron microscopy (SEM) attached with energy dispersive X-ray (EDX) reveal that cryptocrystalline apatite (fluorapatite) is the dominant phosphate mineral. Silt sized silica is the dominant gangue, whereas pyrite and muscovite are present as minor gangue. The phosphate minerals occur as oolites, pellets, and cryptocrystalline apatite in the groundmass. Silica veins form a network replacing the original phosphatic matrix. Brown to brownish black color may be attributed by the organic matter in the phosphatic nodules. Completely phosphatized radiolaria and partially pyritized planktonic foraminifera are observed. There is corroboration of organic matter in the form of microbial filaments in the groundmass of apatite. The findings in the present investigation indicate that the different forms of the minerals, their texture, and distribution in the phosphatic nodules might be due to environmental vicissitudes in oxidizing to reducing conditions followed by replacement processes. Presence of microbial filaments may be due to the active role of microorganisms during the formation of these phosphatic nodules.

By Rodolfo Espinosa Gómez

"Industrias Peñoles, S.A. de C.V. – Mining Division, has initiated in the last ten years, six Mining Operations (Bismark, Tizapa, Ciénega, La Herradura, Rey de Plata, and Francisco I. Madero) and it has expanded several of their existing Operations (Sabinas, Fresnillo, Tizapa, Ciénega) one or more times.This work aims to share the experiences learned on this growing process. Some of these lessons are: 1) Project leaders must have a leadership that fosters good communication and team work; and this leadership style must come from top management. 2) A good communication must exist between the personnel from Engineering, Construction, and Operation. Also, this good communication must come from top management. 3) Starting the project with a solid Engineering Study. 4) Do not misunderstand cost with cost/benefit; always look at the cost/benefit. 5) Selecting good Contractors and good Suppliers. 6) Good training before the project commissioning is essential to reduce the learning curve period, this is even more important in areas where local people do not have any background in mining activities. 7) Recognizing that any project has a learning curve and it must be reflected on the production budget. 8) Avoid an over optimistic Mine preparation time schedule.BACKGROUNDIndustrias Peñoles S.A. de C.V.The mission of Industrias Peñoles, S.A. de C.V. (Peñoles) is to add value to non-renewable natural resources in a sustainable manner. Peñoles seeks to build long-term shareholder value; provide their customers with the highest quality products and services; maintain productive longterm relationship with their suppliers; develop and promote the capabilities of their personnel; foster mutually beneficial relationship with the communities in which it operates, and preserve the environment.Peñoles was established on 1887. It is a Mining Group with integrated Mining, Smelting and Refining operations of non-ferrous metals, and also produces inorganic chemistry materials. Peñoles is the main World producer of refined silver, metal bismuth, and sodium sulphate; Latin American leader in the production of refined gold, lead, and zinc.The Mining Group is made-up of nine mining operations producing concentrates with high gold, silver, lead, zinc, and copper contents. It produced in 2002, 365,900 ounces of gold; 52.7 million ounces of silver; 86,820 tonnes of lead; 266,000 tonnes of zinc, 11,840 tonnes of copper; with a total values of 3,780.6 million of Mexican pesos (~ $ 378.0 million U.S. Dollars)."

Jan 1, 2004

By A. A. Lavrinenko

There are discussed the possibilities of using of flotation tailings of platinum-copper-nickel sulfide ores of the Norilsk region for the preparation of backfill mixture instead of a specially produced rock and binder materials to reduce the cost of stowing operations and impact on the environment. It is shown that due to the presence in the tailings of flotation up to 10% of sulfide sulphur, which reduces the strength of the fill materials, and more than 1 g/t PGM it is necessary the preliminary extraction of the sulfides in the product for further processing that give an opportunity to reduce the losses of valuable components. It is shown that by the flotation of the current tailings it is possible to extract 91% of sulfide sulphur, 60% of palladium and 30% platinum in 17% sulfide concentrate containing 2.1 g/t palladium, and to reduce the sulphur content in the tailings up to 0.7%. Due to the easy oxidation of pyrrhotite, there is recommended fractional delivery of the collector with a total consumption 200 g/t. There are discussed results of the flotation study with an additional collector of PGM (sodium diizobutyditiophosfinate), which one show the possibility to increase extraction of platinum on 45%, as well as extraction of sulphur and palladium. For the flotation of sulfides and PGM from the current tailings there is recommended a combination of collectors for primary flotation and only butyl xanthate using in control operations. The possibility of using sludge fraction of the current tailings as a component for the preparation of the combined cementing materials after exposure of sulfides is analyzed. It is shown that the efficiency of the flotation of sulfides from this fraction can be enhanced using selective flocculants. There are discussed the advantages of implementation of completely hydrophobic butadiene-styrene copolymer in comparison with partially hydrophobic polymers. There is discussed an efficiency of the mechanochemical treatment of old tailings in turbo mill and sulphuric acid to remove oxide films from the surface of pyrrhotite before its flotation. Due to the pretreatment operation there is achieved increasing of sulphur extraction and after the introduction to the flotation circuit three control operations there is produced the fill material with sulphur content 2.5%. Keywords: tailings, copper-nickel ore, pyrrhotite, butyl xanthate, sodium diisobutyl dithiophosphinate, selective flocculation, butadiene-styrene copolymer, mechanochemical treatment

Sep 1, 2012

By Eugene Nel, Johan Theron, Chris Martin, Hans Raabe

"Impala Platinum Limited is the world’s second largest platinum producer, producing more than 1.7 million ounces of the precious metal last year, much of this from the UG-2 reef located in the Bushveld Complex, South Africa. As part of Impala’s ongoing expansion programme, tonnage through their principal UG-2 processing facility, near Rustenburg, was increased 40% in 2001.To accommodate the increased throughput, the role of the existing primary mills was converted from conventional semi-autogenous grinding units, to attrition and selective grinding units, operating in fully autogenous mode. The finer chromite and coarser silicate components in the mill discharge are then separated by screening and processed in dedicated circuits downstream. This way, the need to spend considerable capital to increase primary grinding capacity was averted.In the last year, considerable work has been conducted to evaluate and optimise the two downstream circuits. This has involved an optimisation programme of sampling and diagnostic flotation testing, supported with QemSCAN analysis. This paper will describe the operation of the new circuit. It will also describe some of the more novel aspects and interesting findings from the optimisation programme.INTRODUCTIONThe South African platinum industry is the world’s largest producer of platinum and the world’s second largest producer of palladium. Located in a wide area north of Johannesburg, the industry mines ores from the Bushveld Complex, one of the world’s great mineral treasure chests, containing over 70 percent of the world’s platinum, as well as extensive reserves of the other PGE (platinum group elements), chrome, manganese and vanadium. The industry employs about 180,000 people in, predominantly, underground mines, which together form an almost unbroken circle of mining operations 200 km in diameter."

Jan 1, 2004

By A. F. Khan

The CSense advanced process control (APC) solution?s main objective was to improve the stability of the pH in the first stage leach process thereby improving nickel and iron extraction efficiencies and reducing the base metal (BM) content in the platinum group metals (PGM) concentrate. By improving the stability of the control of the pH on the first stage leach it had the corresponding effect of improving the Ni extraction efficiency by 0.5% and the Fe extraction efficiency by 3.3%. The system relieved the operators of many decisions that were virtually impossible to make given the complex, variable and real-time nature of the processes in their charge. On the operational side, the operators understand the APC system and they trust it. Another benefit is the reduction in pH peaks in the autoclave, which can oxidize certain elements whereby they become difficult, if not impossible, to leach. These elements go right through the process and end up contaminating the PGM solids, with the result that the entire batch has to be recycled through a lengthy and costly processing pipeline.

Jan 1, 2009

By J. J. Harrington

The pH control system at Kennecott Copper Corporation's Nevada Mines Division concentrator consists of two independent systems, lime dilution and lime addition. Lime dilution is accomplished in a mixing tank where slaked lime and water are introduced proportionately. The desired dilution of the milk of lime is determined by the electrical inputs provided by eight pH probes, one per grinding section. The inputs are averaged and applied to a time base generator. The summation output of the time base generator determines the proportion of lime and water that are to be mixed and applies this input to a voltage sensitive switching device. The switching device provides a signal to one of two relays which will add either slaked lime or water, dependent upon the summation output. The entire cycle is based on a two-minute repetition rate to allow for sufficient mix time. Responsivity is controlled by maintaining a limited maxi- mum solution level in the mix tank. Lime addition is controlled independently within each grinding section. The electrical input from the pH probe in a given section controls the solenoid valves which provide lime to each of the ball mills. The valves remain open within a time range capable of maintaining the pH of flotation feed at a given set point.

Jan 1, 1975

By K. G. Stowe

"1. Introduction Mattagami Lake Mines and Orchan Mines operate zinc copper mines adjacent to one another near Matagami, Quebec, situated approximately 300 kilometres north-east of Rouyn-Noranda. (Note: Mattagami Lake and Orchan are in the process of being absorbed by Noranda Mines and will become Noranda Mines-Matagami Division). Both concentrators began operations in late 1963.The Mattagami Lake concentrator is capable of treating up to 3,500 metric tons per day of massive sulphide ore with a mineral composition shown in TABLE 1. The Orchan concentrator consists of two separate circuits - the Orchan circuit with a capacity of 1,050 metric tons per day and a custom circuit with a capacity of 825 metric tons per day. Throughout its operation, Orchan has custom milled ore from several smaller deposits in the Matagami district."

Jan 1, 1979

By E R. Ramanaidou, M Wells

The aim of this paper is to summarise all known Phanerozoic ooidal ironstone deposits worldwide, including Australian deposits such as the well-known channel iron deposits (CID). Nearly 400 occurrences have been catalogued based on stratigraphy, geographical coordinates, facies, grade, tonnage and iron bearing ore minerals. The description also includes details on the geochemistry, genetic models and main references. Brief statistical analysis provides an overview of the variation between these deposits. This compilation offers a basis for better understanding of the ooidal ironstone deposits and a global evaluation of this important resource worldwide.

Jan 1, 2009

By Ann Hubbs, Vincent Castranova, Jane Y. C. Ma, De-Hwa Chao, Joseph K. H. Ma

AN OVERVIEW OF THE ACTION OF TETRANDRINE ON SILICOSISBecause of the persistent presence of silica dust in the lungs silicosis is a progressive and irreversible disease. At present, there is no proven effective therapy for silicosis. Limited choices of therapeutic intervention with corticosteroids and other immunosuppressive regimens 1,2 have been accepted for some forms of pulmonary fibrosis. These treatments are only minimally effective, and the results provide little understanding of the disease state due to the lack of correlation between drug activity and the mechanism of fibrosis. Thus, continuing effort must be made in the search for effective antifibrotic agents, which may be used to provide a sequential analysis of the fibrotic process and to open the door for further research and clinical development. Tetrandrine is one of hundreds of drugs screened for antifibrotic activity by Chinese scientists. It has been used in China as a treatment for silicosis in open clinical trials3 and in laboratory animals. The action of tetrandrine on pulmonary fibrosis has been attributed to its ability to inhibit particle stimulation of alveolar macrophages, a key cell type central to the fibrotic process, to release oxygen radicals and inflammatory cytokines. Alveolar macrophages (AM) residing on the alveolar wall, are the predominant phagocytic cells of the lungs responsible for pulmonary defense against inhaled microorganisms and other particles and thus play an important role in maintaining the homeostasis of the lungs. 7 Ample evidence suggests that cells of the monocyte-macrophage series play an important role in the immunopathogenesis of pulmonary fibrosis. When upregulated by silica, alveolar macrophages generate reactive oxygen metabolites8·9 which can damage lung parenchyma and release fibrogenic growth factors and cytokines, 10,11 such as interleukin 1 (IL-1), which can induce fibroblast proliferation and collagen synthesis. The cytokine-mediated fibroblast proliferation and collagen synthesis are key steps in the development and progression of pulmonary fibrosis .11 Previous studies by our group have shown that tetrandrine exhibits strong binding affinity to AM and inhibits particle-stimulated respiratory burst activity (oxygen consumption, superoxide anion release, and hydrogen peroxide secretion) in these cells. 13 In addition, studies by Kang et al. 14 have reported that tetrandrine inhibits silica-induced release of fibrogenic factors such as IL-1 which are capable of inducing fibroblast proliferation and collagen synthesis. Reist et al. 15 further suggested that the antifibrotic action of tetrandrine may be mediated in part by the direct effect of this drug on the ability of fibroblasts to respond to proliferative agents. These results indicate that the mechanism of silicosis involves activation of AM and fibroblasts by silica, resulting in abnormal collagen production due to miscommunications between the cell types. Tetrandrine may interrupt this process by direct interaction with the lung cells.

Jan 1, 1998

By M. L. Fuller

MOST commercial alloys undergo changes in phase composition after casting. This is a natural result of the fact that the alloys are not in a state of phase equilibrium as cast and phase changes will therefore take place, with more or less rapidity, in an attempt to attain equilibrium. The practical aspect of aging in zinc-alloy die castings concerns the changes in physical properties and in dimensions that may accompany aging phase changes. Harmful alterations have been reduced to a minimum and zinc-alloy die castings are being produced today that are so stable with respect to dimensions and physical properties that they are entirely suitable for most practical purposes1. In the first paper2 of this series, and in this paper, aging phase changes of zinc alloy die castings have been investigated and the possible influence of these changes on dimensional changes of the castings has been evalu-ated and compared with the dimensional changes actually experienced. The change of dimensions has been selected for practical comparison in these papers because the effect of phase changes on the dimensions of a casting is directly calculable; from X-ray crystal-analysis data of the phase structure. The die-casting alloys considered contain, in addition to zinc, 4 per cent of aluminum, about 0:03 per cent magnesium, and from 0 to 3 per cent of copper. It was shown in the former paper that the eutectoidal decomposition of the beta aluminum-zinc phase, while intrinsically capable of causing a considerable shrinkage, can have very little effect on the observed shrinkage of die castings because it takes place within a few days of aging, whereas the observed shrinkage continues for five weeks. It was therefore concluded that the other existing phase change,

Jan 1, 1935

By Xiaowen Liu

The DSC/TG, IR and XRD analysis were used to characterize the heating phase transformation of illite, which came from Ouhai deposit, China. It was discovered that the dehydration and de-hydroxylation of illite carried out stage by stage during heating. The adsorptive water and layer-inter water were dehydrated from room temperature to 500°C; and dehydroxylated in the range 500°C~800°C. In these stages of process, illite?s layer structure kept almost unchanged. After 800°Cillite began to change into disorder structure. At about 1100°C, the layer structure of illite had been destroyed, and amorphous SiO2 and mullite crystallite appeared. At about 1200°C the structure of illite completely destroyed and mullite crystal phase had become perfect..

Jan 1, 2006

By C. S. Kucukkaragoz

An ilmenite concentrate was reduced in the solid state with carbon under argon atmosphere at temperatures between 1000oC and 1400oC. The ilmenite concentrate and 50% excess carbon were reacted to achieve the highest attainable degree of reduction at each temperature and the reaction products were subjected to a series of analytical work by optical microscopy, X-ray diffraction analysis and SEM ( EDS) analysis. The ilmenite remained unaltered at 1000oC and had a slight change in its composition at 1050oC. A secondary oxide phase containing metallic nuclei was detectable at 12% reduction at 1100oC. The reduction of TixOy took place in a sequence changing the y/x ratio from 2.0 to a value less than 1.0 at 84% reduction at 1400oC. Metallic phase consisted of Fe and C initially and started to include Ti at the later stages. Complete reduction of TixOy to metallic Ti was not possible at these temperatures.

Jan 1, 2005