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By S. L. Weber, V. Castranova, D. E. Banks, J. K. H. Ma, Y. Rojanasakul, J. Y. C. Ma, M. Bhat

"The mechanism of bleomycin-induced pulmonary fibrosis is not ye: clear. Recent studies have shown that alveolar macrophages (AM) can be stimulated by bleomycin in vitro releasing inflammatory cytokines, suggesting that the interaction of bleomycin with AM is an important step in the drug-induced fibrotic process. Bleomycin is known to bind DNA and generate oxygen radicals through complexation with Fe2+ and oxygen. To provide,more insight into the cellular oxidative property of bleomycin, v.s have developed a fluoromicroscopic method using 2',7'-dichlorofluorescin diacetate (DCFHDA) as an oxidative fluorescence probe to study the deomycin-induced intracellular oxidation in rat AM and the inhibition of the oxida¬tion by taurine, a compound known to inhibit the bleomycin-induced fibrosis. Bleomycin at 5 to 20 ug/ml has a moderate stimulatory effect (1.87- to 2.66-fold) on the secretion of superoxide anion. A high concentration of bleomycin (20 ug/ml), however, inhibits cell response to zymosan-induced secretion of superoxide anion. At 4 ug/ml, bleomycin has no effect on cell membrane integrity or morphology but results in a significant increase in intracellular oxidation. This oxidative process is Fe2-,-dependent and is accompanied by an increase in intracellular calcium (35 nM). Both the intracellular oxidation and calcium rise induced by internalized bleomycin are inhibited by pretreatment of cells with varying concentrations of taurine (25, 125, and 187.5 uM). The inhibitory effect on intracellular oxidation .vas found to be 36, 57, and 60%, respectively. These results demonstrate a stimulation-inhibition relationship between bleomycin and taurine on re cellular oxidation at a subcytotoxic dose of bleomycin, suggesting that the oxidative effect of the intracellular bleomycin-Fe2 complex is important in the initiation of the fibrotic process. — Environ Health Perspect 102 (Suppl10):91-96 (1994) IntroductionThe pulmonary system is most susceptible to oxygen radical-induced diseases due to its constant exposure to the highest oxygen tension, and the potential encounters with oxidant gases such as ozone, nitrogen oxides, and toxic doses of dust particles. The lung is also a well-perfused organ and thereby vulnerable to the effect of circulating xenobiotics such as paraquat, and, bleomycin, which is known to cause pulmonary injuries (1). Alveolar macrophages (AM), which act as a means of defense by phagocytizing inhaled dust particles and microorganisms while increasing production of reactive oxidative species, have been shown to play an important role in mechanisms leading to oxidative lung injury and fibrosis (2-4)."

Dec 1, 1995

By Kevin Erwina, Rajiv Chandramohana, Connor Meinkea

This paper explores prevalent operational challenges encountered globally in SAG mills, including suboptimal throughput, liner wear, excessive energy consumption, and SAG mill load stability. The paper delves into the root causes behind these issues, such as ore variability, poor operating strategy, or inadequate process control. Drawing on industry experience and case studies, the paper highlights the significance of addressing these challenges to enhance overall mill performance and efficiency. It underscores the necessity of tailored strategies, encompassing improved monitoring, optimized liner designs, and refined control techniques to mitigate these challenges and promote sustainable SAG mill operation.

Feb 1, 2024

By Trevor R. Ellis

"The valuation of mineral properties in the U.S. is only partially regulated. The regulations which have jurisdiction or impact appear to have such mainly as a consequence of unintended fallout, since the regulations were designed for other purposes. Court case history can also be important. The combined results are a mixture of bad and good, with important lessons to be learned.Since 1981, the Securities and Exchange Commission has prohibited U.S. listed companies from reporting quantitative estimates of mineralization and the value of mineralization, other than proven and probable reserves. This results in the minerals appraiser (valuator) working with a shortage of data in his everyday work, both on the subject property and in sales analysis.Between 1989 and 1995, all 50 states and essentially all Federal agencies adopted the Uniform Standards of Professional Appraisal Practice (USPAP) for real property appraisals (valuations). The major national appraisal societies also require their members to abide by USPAP. A significant portion of minerals appraisals must now follow these standards. This paper will discuss the content of USPAP. It provides a very good framework for the valuation of a minerals property or a mine, both as real property and as a business. However, the credentialing standards for real property appraisers are now prohibitive for minerals appraisers."

Jan 1, 2003

By N. A. C. Smith, E. W. Dean, W. A. Jacobs, H. H. Hill

Fractional distillation is the most important process in the commercial refining of petroleum. The same procedure, conducted on a small scale, is the basis of a number of analytical methods of wide application in the petroleum laboratory. The Bureau of Mines has studied apparatus and procedure for the distillation analysis of petroleum, and this report is presented as a record of developments up to the present time. The work is incomplete, but the extensive information that has been obtained to date is made available as a guide in handling laboratory distillation problems. The analytical distillation of petroleum is commonly made to determine range of boiling points or to separate the oil. into fractions for detailed examination, or both. When only one of these two ends is sought the procedure involved is notably simpler than when, as is more common, information is required regarding both boiling range and properties of fractions. Moreover the degree of minuteness of measurement and the accuracy of the data required from analytical distillations differ considerably. Often the simplest sort of comparative figures are satisfactory; other tests require complicated and highly tedious procedure. No one distillation method is universally applicable, and it is impossible for anyone group of investigators to foresee all the different kinds of requirements that may occur in the industry.

Jan 1, 1922

By Anna Carolina Cerqueira Neves

As fibras sintéticas vêm sendo gradualmente substituídas por fibras naturais. Em comparação com a fibra sintética, fibra natural demonstrou vantagens econômicas e ambientais. Visto que apresenta características interfaciais com matrizes poliméricas que favorecem a absorção de energia de alto impacto pela estrutura. No entanto, até agora pouco foi avaliado sobre a fibra de cânhamo incorporada em matrizes poliméricas. Este estudo tem o objetivo de avaliar a resistência ao impacto deste tipo de compósito com matriz de poliéster reforçada com diferentes porcentagens de fibras de cânhamo. A resistência ao impacto aumenta proporcionalmente com a quantidade relativa de fibras incorporadas como reforço na matriz polimérica. Este desempenho foi relacionado com a dificuldade de ruptura imposta pelas fibras, resultante da interação da matriz de fibra de cânhamo / poliéster de forma a ajudar a absorção da energia de impacto.

Aug 17, 2017

By D. Mark Richards

Highland Valley Copper (HVC) is a large open pit copper mine in the southern interior of British Columbia. Machine guidance technology using GPS has been utilized at the mine since 1996 for blast hole drill navigation and since 2000 for shovel and dozer navigation. Since 1997, rock recognition has been part of the drilling process. This allowed the mine to develop a Mine to Mill strategy using the rock hardness information from drill monitoring systems to both refine drilling and blasting parameters as well as downstream crushing and grinding strategies. Although this preliminary effort has been very successful at HVC, the current intent is to gain further benefits through better use of existing information while also deriving an enhanced data set from monitoring production drills. In the latter case, the objective is to acquire and process drill variables in such a manner as to permit more detailed definition of rock mass characteristics. The subsequent focus will be to use the derived geotechnical and geological information as part of a practical process to more prescriptively blast the rock mass. Through the definition of domains based on drill monitored derived rock mass properties, the intent will be to enhance blast outcomes that lead to optimized downstream (from blasting through to concentration) processes in a more proactive and timely manner. This paper examines a proposed approach to be able to derive more accurate and consistent rock mass properties from production drilling. In addition, the discussion will identify potential benefits to be gained from process improvements that result in enhanced productivities, and crushing and grinding optimisation due to blasting strategies that are more closely matched to identify rock mass characteristics.

May 1, 2007

By J-F. Béland, N. Parson

Aluminum extrusions are widely used for automotive crash management systems due to their superior specific energy absorption capabilities, as compared to steel. The Al-Mg-Si alloy series can be readily extruded into complex multi-hollow profiles, as required in crash systems, and can be used to target a range of desired strength levels. This paper focuses on the development of an axial crush test protocol and evaluation of the crush performance of common 6XXX series alloys for a variety of tempers. The observed crush behaviour is then compared to tensile test results.

Jan 1, 2015

By Stephen Utter

Stresses induced by block-caving mining were estimated from in-place measurements of strain or deformation in rock and concrete around mine openings. The four types of gages used for measurements in the Climax Molybdenum mine during 1959-61 were Whittemore gage, Carlson strain meter,2 Valore strain cell, and Climax extensometer. Gage performance in the laboratory was evaluated by stressing instrumented rock and concrete specimens in a universal testing machine and by comparing measurements taken by the gages and a standard gage. Gage performance in the mine was evaluated by comparing measurements taken during an 18-month test. The Whittemore gage, Carlson strain meter, and the Climax extensometer proved suitable for the investigation; the Valore strain cell, effective in the laboratory tests, gave erratic measurements in the mine.

Jan 1, 1965

By Caruline de Souza Carvalho Machado

Tensões residuais podem ser muito prejudiciais ao desempenho de um componente, tornando sua quantificação e avaliação extremamente uteis. A difração de raios-X é um método de análise não destrutivo que permite avaliar as tensões sem comprometer o material. Neste trabalho, tiras de aço duplex UNS S32304 com 1,8mm de espessura foram cortadas nas dimensões 36x72mm e soldadas de modo autógeno através do processo TIG. Produziram-se dois tipos de amostras variando-se o gás de proteção a saber: mistura de argônio 98% e nitrogênio 2% e argônio 99.995%. Utilizou-se um difratômetro com geometria Bragg-Brentano, fonte de radiação CuKa ( = 1,5419Å). A técnica sen2 ? foi empregada para determinar a tensão residual da fase austenita no ângulo 2?=146.22°. Os resultados mostram um estado de tensões residuais trativo nas proximidades da zona fundida, chegando a um estado compressivo em regiões distantes. A análise comparativa dos perfis de tensão residual revela que a amostra soldada apenas com argônio apresenta menor tensão residual trativa na zona fundida.

Aug 8, 2018

By Sebastião Raimundo de Jesus Bélem Leitão Filho

A simulação física é uma alternativa no estudo dos eventos durante o processamento termomecânico, sem necessidade de equipamentos industriais, permitindo a realização de projetos de deformações similares as de escala industrial, porém em diferentes condições de atrito e transferência de calor. O objetivo desta pesquisa foi investigar o retardo na cinética de amaciamento estático no aço inoxidável austenitico ASTM F-1586, usado na confecção de implantes ortopédicos. A metodologia aplicada consistiu no cálculo da fração de amaciamento (Xs), após realização dos ensaios de compressão a quente com duplo passe de deformação num dilatômetro, nas temperaturas de 1000 - 1200 oC, taxa de deformação de 1,0 s-1 e intervalos entre passes variando de 1 a 1000 s. Os resultados indicaram que o aço ASTM F-1586 sofre recristalização metadinâmica em deformações maiores que 0,30, onde as curvas Xs vs. t para temperaturas abaixo de 1100 oC apresentaram formação de patamares com atraso na cinética amaciamento, resultante da interação recristalização-precipitação (Fase Z) induzida por deformação no interpasse, sendo menos efetivo quanto maior a temperatura e a deformação.

Oct 30, 2017

By Federico Pagliacci, Marco Chiarabelli, Salvatore Miranda

The paper describes the adopted technologies and performance controls related to a special geotechnical engineering solution provided within the scope of the Galataport Project, in Istanbul, Turkey. The scheme is the one applied to the new quay of Salipazari, which is a combination of retaining structure and ground improvement, formed by a combi-wall, a reinforced concrete diaphragm wall and a soil improvement by deep soil mixing (Turbojet). The paper highlights the importance of employing cutting-edge technologies within the foundation engineering field and state-of-the-art electronic control devices, in parallel with the essential human expertise, in order to obtain the desired results in this high profile Project. The results of the in-situ and laboratory tests carried out on the improved soil are also presented. Main discussed points are: • History of Galataport and main Project details. • Design principle and soil condition for the new quay of Salipazari. • Difficulties encountered during execution of DSM. • Preliminary field trial tests conducted to establish the operational parameters, with relevant in-situ and laboratory tests executed. • Preliminary tests on material used for DSM (seawater and CEM IV SR). • Electronic equipment mounted on the rig, which allows the automatic execution of DSM columns. • Final QA/QC tests conducted to verify the performance of DSM, mainly consisting in: coring with relevant laboratory tests on samples (UCS + Es), seismic refraction tomography and seismic cross hole tomography. Correlations between UCS and Es, and between Es and Edyn are also presented. • A cross section of the executed treatment could be inspected on site during excavation. Photos and considerations are also presented.

Jan 1, 2018

By Robert H. Peters

Several significant problems associated with employee turnover among underground miners are described in this Bureau of Mines report. Although a vast amount of research has been conducted on turnover among employees in nonmining industries, there has never been an attempt to empirically investigate the causes of turnover among underground miners. This report presents the results of empirical research on employee turnover in other industries and describes and critiques the research methods that have been used to investigate turnover. Using the findings on employee turnover in other industries and known data about miners and the mining industry, a conceptual model of the factors that cause turnover among miners was generated. This model, which is expected to provide a basis for later empirical studies, is presented. Several recommendations for controlling miner turnover are also presented.

Jan 1, 1986

By C. H. Fisher

[Many methods of analyzing tar oils for their tar acid and base content have bun employed in connection with both academic and. industrial investigations. Most of these analytical procedures are based on the diminution in volume caused by extraction with alkali and mineral acids (contraction method), although other methods haves been employed.4/ In many instances the adoption of an analytical method was not preceded by adequate study, and, as a consequence, the literature, on this subject is conspicuous for its contradictory claims and recommendations. It has bin shown in the, case of certain synthetic solutions5/ that large errors may result if the analysis is carried out by simple extraction with alkali and mineral acids.]

Jan 1, 1936

By P Vasconcelos, X D. Deng

Numerous supergene manganese oxide deposits are developed inSouth China as a result of weathering of a thick sequence of Paleozoic marine Mn-bearing sedimentary rocks, consisting mainly of limestones, cherts and black shales that were intensely folded and faulted due to multiple episodes of tectonism since the late Triassic. The ore minerals are dominantly pyrolusite, cryptomelane, nsutite, lithiophorite and braunite. The supergene manganese ores contain Mn ranging from 20 to 44 wt per cent; manganese oxide deposits derived from cherts and black shales also contain recoverable levels of Co, Ni, Cu, Pb and Zn. 40Ar/39Ar dating of potassium-bearing manganese oxides reveals that extensive supergene manganese ore formation started at least in the earliest Miocene and persisted to the Present. Ages of the deposits show a close correlation to tectonic stability, with the oldest in tectonically quiescent areas and the youngest in active areas that have subjected to continuous uplift and thus significant denudation. The prolonged wet and hot climate since Oligocene and the balance between weathering and erosion, which is parameter to the tectonic stability, are the ultimate controls on the formation and distribution of South China supergene manganese oxide deposits. An EXTENDED ABSTRACT is available for download. A full-length paper was not prepared for this presentation.

Jan 1, 2008

By Per Eriksson

For light buildings on clay, foundations on L/C-columns is in many cases a competitive alternative to piles when the thickness of the clay is moderate (<20 m). The method is applicable for the above mentioned depth when the clay is normally consolidated, and for thicker deposits when the clay is overconsolidated at depth. This case study concerns a shopping mall in Nordby, Sweden, founded on L/C-columns (5-15 m in length) and generally spaced 1.45-2.0 m (spacing 0.7 m was used below pillars). The base slab was built as a raft foundation, using fibre reinforced concrete.

Jan 1, 2000

By Tom Szynakiewicz

Micropiles are routinely used in the United States for foundation support and underpinning applications. The high capacities achievable with the use of micropiles, combined with specialty rigs for easy installation in low headroom and difficult access areas makes them a good choice for situations often encountered on existing commercial projects. The bond zone of the pile is typically drilled into a competent stratum such as sands, gravels or bedrock. In this paper, the authors will discuss a project where the lack of a shallow ?competent stratum? led the geotechnical contractor to create their own bond zone for the micropiles using jet grouting. Due to problematic clay (CH) soils, the original foundation of a six story office building in west Houston had experienced up to five inches of differential movement in-between the shallow under-reamed shafts. The owner desired a permanent solution to the problem without disturbing the majority of the tenants. The structure was underpinned with a hybrid system of jet grouted micropiles as well as jet grouting alone and the structure was re-leveled using hydraulic equipment to within a 0.25? tolerance. Design, construction and sequencing of the project are discussed in the paper. QA/QC methods are also discussed, including coring for verification of jet grout column diameter as well as a full-scale micropile compressive load test. The structure was successfully re-leveled and the entire project was completed without disturbing any tenants on the floors two through six.

Jan 1, 2008

By Oliver Bowles

[Simple systematic accounting that adequately records all transactions has long been regarded as essential to the welfare of any business enterprise. Some of the defects that detract from the prosperity of the slate industry are attributable to a lack of effectiveness in cost keeping. This condition has promoted the United States Bureau of Mines to make a detailed study of accounting methods for the slate industry, and to present for consideration a system of accounts, which it is believe would enable the industry to attain more economical management and operation if accepted by a fair proportion of its important units. The method of accounting presented herein has been worked out with the assistance of leading slate producers and the recommendations are tentative and are submitted in this form as a means of developing constructive criticism. Believing that cooperative effort in this, as in many ether problems will bring the most enduring benefits to the industry as a whole, the writer urges that the cost earnest consideration be given to this vital problem now facing the slate industry.]

Jan 1, 1929

By B. R. Broekman, D. W. Penman

Discussion by P.J Lloydt Broekman and Penman describe (J.S. Afr. Inst. Min. Metal., vol. 91, Aug. 1991, p. 261) the addition of sodium cyanide and zinc sulphate to the flotation feed at Prieska. They note that for &apos;safety sake, lime was added to the rod mil to raise the pH to 9,5&apos;, and that &apos;personnel working in the vicinity of the rod mil were required to wear gas masks&apos;. Author reply to P.J. Lloyd We thank Dr Lloyd for his interesting contribution. As he correctly points out, the Prieska float had run with cyanide solutions at pH values of 6,4. In fact, it ran safely for extended period with the pH slightly below 6.

Jan 1, 1991

By Craig Hartley

? A helper stands beside a continuous miner as the operator is at the controls. The operator means to push the stop button but hits the drum rotation start button by mistake. The drum begins to turn and the bits catch the helper&apos;s clothing. He is thrown violently to the ground and suffers multiple contusions. ? A farmer&apos;s wife helplessly watches her husband drawn into the claws of farm machinery while she frantically and unsucessfully searches for the control to stop the machine. ? A mechanic on the night shift replaces plugs in the lubrication systems of all three engines of an airliner following routine maintenance. In doing so&apos;, he fails to notice that "0" ring seals have not been mounted on the plugs. A few hours later, as the fully loaded airliner is cruising high over the ocean, oil pressure on one engine drops precipitously. The pilots quickly shut down the engine and turn for home. Almost immediately, the two remaining engines lose their oil and fail.

Jan 1, 1983

By J. B. Salsman

As part of the research effort on investigating the effects of microwave energy on the chemical and physical properties of minerals and ores, the U.S. Bureau of Mines (USBM) Tuscaloosa Research Center has conducted research to measure the dielectric properties of these materials. The objective was to establish a reliable database for use in predicting the effects of microwave heating on a wide range of minerals. The dielectric constants and loss factors of minerals, commonly referred to as the dielectric properties, were determined utilizing the theory of microwave propagation through an open-ended, air-filled coaxial line that was terminated at its open end with the particular mineral under investigation. In this phase of microwave research, the USBM measured the dielectric properties of powdered minerals with medium to high electrical conductivities in the frequency range of 300 MHz to 3 GHz and as a function of temperature from 25 to 325 °C. Since the minerals were prepared as powders, techniques were used to relate the measured dielectric properties of the powdered minerals to the dielectric properties of the mineral at its theoretical or natural density.

Jan 1, 2010