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By V. Castranova, L. Wu, K. Van Dyke, J. Gutierrez, V. Vallayathan

Since it has been demonstrated that silica caused phagocytic cells to activate lipoxygenase metabolism of unsaturated fatty acids we thought selective inhibition of this metabolic pathway might be helpful in treatment of silicosis. It is known that lipoxygenase metabolism plays a role in the pathogenesis of a variety of inflammatory and hypersensitivity conditions. Further, it is believed that the alveolar phagocytic cells which engulf silica begin the inflammatory cycle which produces the metabolic products, cytokines and growth factors which causes fibrosis in the lung. There have been indications that drugs which inhibit lipoxygenase can inhibit fibrosis from other causes. Previously, we developed a method which detects the activity of lipoxygenase metabolism by measuring free radical oxidation via light production or chemiluminescence (CL). We decided to apply this method to phagocytic cells that would be found in the lung in the presence of silica with and without newly developed inhibitors of the lipoxygenase reaction. We used drugs which inhibit lipoxygenase directly including AA861 (TAKEDA), A63162 (Abbott), and an inhibitor that scavenges free radicals produced from the lipoxygenase reaction, nordihydroguairetic acid. In addition we used an indirect inhibitor, tetrandrine. We found drug inhibition of silica activated CL from alveolar macrophages, neutrophils and human leukemia (HL-60) cells differentiated with DMSO. Nordihydroguairetic acid 2x10-5M produced almost complete inhibition in all three cell types. In human leukemia cells (HL-60) A63162 and tetrandrine were equally inhibitory at 42% while in human neutrophils A63162 and tetrandrine were less active 22 and 10% respectively. In macrophages A63162 and AA861 were less than 50% inhibitory to cellular CL at 2xl0-5M. Direct assay of tetrandrine (2x10-5M) with sodium arachidonate and soybean lipoxygenase reveals no inhibition. All antilipoxygenase drugs regardless of mechanism were inhibitory to cellular chemiluminescence from all three types of phagocytic cells. These drugs alone or in mixtures could prove useful in treatment of silicosis.

Jan 1, 1991

By Gabriel E. Zárate, Juan C. Guzmán

In Chile there are significant amounts of gold in flotation tailings that could be recovered, being heap leaching the most promising alternative. In order to determine the feasibility of treating these tailings by this method, a detailed study is carried out using 4 representative samples. After defining the best conditions an economic evaluation is done for a plant treating 200 tpd, sensibilizing with respect to parameters such us gold price, tailing grade and capital costs. The results show that it is technically feasible treat these gold tailings by heap leaching with gold extractions over 70 %. It is also economically feasible for gold grades higher than 0.5 g/t and gold prices over 350 US/oz.

Jan 1, 1987

By E. B. Johnson, G. Kjerbol, L. J. Holloway

The Mount Baker Ridge Tunnel is a major improvement of Interstate Route 90 in the State of Washington. The total length of planned underground construction is about 3,400 feet (1,040 m) of which 1,332 feet (406 m) will be constructed by a stacked-drift tunneling method. Sized for vehicular traffic on two levels, the net interior diameter will be 63 feet (19.2 m) requiring an exterior diameter of about 80 feet (24.4 m). The material to be excavated is predominantly stiff clay, and this will be the largest-diameter tunnel ever attempted in soft ground. A construction contract for the stacked-drift tunnel was awarded in late 1982.

Jan 1, 1983

By John C. Balla

The Troy deposit is located in northwestern Montana, approximately 17 mi south of Troy. The deposit is a stratiform, strata- bound, copper-silver deposit which occurs in the Revett formation of the Proterozoic Belt Supergroup. The Revett formation is approximately 1730 ft thick in the vicinity of the Troy deposit, and is divisible into three units. The upper Revett, approximately 250 ft thick, is the host for the orebody. The Revett represents a deltaic environment. The Troy deposit was discovered by Bear Creek Mining Company in 1 963 during the course of a reconnaissance stream sediment sampling program that was designed to discover strata-bound copper deposits. The deposit is approximately 7500 ft long, 1800 ft wide, and averages 60 ft thick. It is bounded on the north by outcrop, on the east by a post-mineral fault, on the south by diminishing grade and post-mineral faults, and on the west by diminishing grade. Ore reserves are 64 million tons with a grade of 0.76% Cu and 1.58 oz Ag per ton. The mine is presently operating at a production rate of 4.2 million oz of silver and 20,000 tons of copper per year.

Jan 1, 2013

By K. A. Brame, L. G. Austin, R. S. C. Rogers

The breakage parameters of phosphate ore were determined by batch first-ordering grinding studies in a laboratory ball mill according to the Austin, Klimpel, and Luckie procedures. The results were scaled to five larger mills of 0.56, 0.82, 8.36, 4.41, and 5 m in diameter assuming equilibrium ball charges for the full-scale mills. The results were used to predict product size distributions and capacities for batch grinding in the smaller mills and open-circuit grinding in the larger mills. The predicted capacities were in approximate agreement with experimental values except for the 5-m diam mill. The Bond method gave capacity predictions that were 4570 to 150% too high.

Jan 1, 1987

By J. L. Post

A near-surface body of readily available Na-montmorillonite is located about 24 km (15 miles) southeast of Fallon, NV. The clay, which forms an irregular deposit about 4.8 km (3 miles) long, lies in altered rhyolite within a fault zone. The clay is similar to Wyoming bentonite but is less uniform in composition and contains less MgO and more Fe2O3 in its crystal structure. The clay interlayer cation population can be estimated by using a modified DTA procedure. With selective mining, the industrial properties of the Nevada clay are adequate for use as drilling mud, in foundry applications and as a sealant for hazardous wastes and canals.

Jan 1, 1997

By Rilung Xu, Jerry C. Tien, Jian Liu

As underground mines become deeper and ventilation networs more complex, ventilation data becomes more complicated and voluminous, making timely ventilation planning and necessary changes more difficult. Oftentimes, ventilation engineers have to rely on special techques using graphs and schematic maps to carry out necessary ventilation planning [1, 4, 5, 6, 9, 10, 11, 12]. A different graphical method, similar to that reported by Taminago and Isobe [10], has been developed in China [13]. This method uses a two-dimensional diagram drawn from available ventilation survey results. It combines both the customary pressure-quantity diagram and ventilation schematic map, and can greatly expedite the interpretation of survey results, facilitate ventilation system design, short and long-range planning, and emergency planning.

Jan 1, 1993

By Mark Gershon

This paper describes a linear programming (LP) application that schedules mining operations in an optimal manner. The model is developed such that it can be applied to a broad spectrum of mining activities. While linear programming has been applied to mine scheduling in the past, the models have been either site-specific or they have only optimized one aspect of mine operations without regard to others. The Mine Scheduling Optimization (MSO) concept makes use of a mathematical model to: (1) Determine the optimal operation of a mine, from mine to plant to market. (2) Account for mine-plant-market interfaces. (3) Optimize operations over the life of the mine. (4) Accomplish long, intermediate, and short range planning.

Jan 1, 1982

By Joaquin Ruiz

Although Mexico is known for its important base-and precious-metal deposits, and lately oil, some industrial minerals play an important role in the Mexican economy. Sulfur, the most important industrial mineral produced, accounts for approximately 7.5 percent of the total value of mineral production. This commodity is followed by fluorspar, which accounts for 6.4 percent. Predominantly, the fluorspar deposits are very high grade (75 percent CaF) and are contained in lower Cretaceous limestone in the states of Coahuila and San Luis Potosi. Base-metal deposits in the area of Parral (notably San Francisco del Oro), however, have become important fluorite producers in their own right. (San Francisco del Oro has 12 percent fluorite gangue.) Salt from the Guerrero Negro solar-evaporation ponds in Baja California account for 6 percent of the total shares; phosphate from Baja California also accounts for 6 percent. Barite from man to deposits in Lower Cretaceous limestone in Coahuila and exhalative deposits in the Paleozoic section of Sonora account for 1.0 percent. In addition, Mexico is an important producer of gypsum, graphite, and celestite. Although graphite and celestite are not large-scale operations and thus do not contribute much to the Mexican economy, the Mexican graphite and celestite deposits are among the most important in the world; Mexico is one of the world's few sources of celestite. The celestite is in the form of large, high-grade mantos in Cretaceous limestones in northern Mexico.

Jan 1, 1987

By P. F. R. Altounyan, I. W. Farmer

Groundwater freezing was used to stabilise 8m thick beds of saturated and weakly cemented sands at a depth of 170m, during driving of twin 1 in 4,5.2m o.d. circular drifts from the surface to the Coal Measures through 600m of Permo-Triassic strata. Instrumentation was installed during erection of the lining in frozen and unfrozen ground to measure ground and groundwater pressures on the lining and ground temperatures up to lm into the frozen ground. Observations showed that following thawing, effective lining stresses in the frozen zone were low, indicating minimum strata disturbance during freezing and subsequent machine excavation. Groundwater pressures were lower than expected.

Jan 1, 1981

By Gealy W. Wallwork

The administrative processes of coal mines are becoming increasingly complex. As society evolves into a more complicated structure with greater emphasis on individuality, government regulations reach deeply into every activity in an effort to force individuals into a standardized mold. These contradictory pressures add an extra burden to the administration of a mining operation. Recent years have brought a substantial change in the skills needed by mine supervisors and managers. As a result, a better understanding of the administrative functions is necessary. The mine superintendent has the overall responsibility for the mine; for effective operation he must be sufficiently knowledgeable to oversee all the complex functions that make up the mine. This chapter does not cover all the administrative requirements because of the variation in mine operation and in company policies and organizational structure. It does attempt to identify the administrative functions that would be required at a large mine with a preparation plant. It is assumed that the mine operation is decentralized with very little duplication of functions at the organizational levels above the mine. Thus each function is assumed to be relatively complete at the mine and under the general supervision of the mine superintendent.

Jan 1, 1981

By Harry R. Asche, Manfred K. Lechner

The Cross City Tunnel comprises 2km of a new underground traffic route in Sydney, Australia. The route is very complex, involving some six separate tunnels and three underground Y-junctions. For almost 200m the six tunnels run parallel at different level sunder William Street, Sydney. Almost all of the route runs adjacent to the City Business District of Sydney and adjacent to or below many major buildings and services. The planning and design of this project is described. The geometric arrangement is achieved with a strong dependence on 3D road design packages. Road alignment constraints include land acquisition and proximity to existing tunnels and basements as well as maintaining separation from the other tunnels in the scheme. Geotechnical and hydrogeological studies are described. Findings discussed include the high horizontal stress field in the Sydney area and investigation of incised palaeochannels on the route. Methods of design for the tunnels and Y-junctions are described, as well as methods of settlement prediction for the buildings and services. The latter includes the settlement assessment for more than 200 buildings, many in excess of 20 storeys, as well as services including all of the city railway lines in Sydney.

Jan 1, 2003

By Wayne W. Murdy

Since 1993, Newmont Mining has been growing through the development 'q of three major foreign mining operations with a fourth under construction. The first project, Yanacocha in Peru, began operating in October 1993. This occurred at a time when political and business risk in that country was considered high. In 1995, Newmont began operating the Muruntau joint venture in Uzbekistan. It is the first mining project of its kind in the Confederation of Independent States (CIS). In early 1996, Newmont started operating the Minahasa Mine in Indonesia. In early 1997, Newmont began construction of a $1.9-billion project in Indonesia. The company is also completing a feasibility study with its partner for the development of a gold operation in Mexico. All of these projects have been considered "risky" by most standards. Newmont has been successful in all of them through risk mitigation programs. These programs include using strong and successful in-country partners, concentrating on developing a strong national workforce with minimal expatriate employees, using World Bank, European Bank for Reconstruction and Development (EBRD) and International Finance Corp. (IFC) financing and building and maintaining strong ties with host governments.

Jan 1, 1997

By Aldo F. Barsotti

The production and consumption of industrial minerals in the United States traditionally have played important roles in mining and in the supply of the bulk of basic raw materials to the economy. This diverse group of minerals extracted and consumed by a variety of industries accounts, on a weight and volume basis, for most mineral-based products consumed in our economy. Industrial minerals form the bulk of the basic raw-materials feedstock for most of the construction, agricultural, and inorganic-chemical-manufacturing sectors, and a good portion of the transportation, manufacturing, organic chemical, and service sectors of the U.S. economy. In this presentation, I discuss current estimates of the amount and value of industrial minerals mined compared with all mining in 1997. I then present a summary of 1997 production of industrial minerals by several end-use industries. This is followed by a historical perspective of the consumption of industrial minerals as a subset of all basic materials, with special emphasis on the aggregates industry. The presentation concludes with a look at the geographic distribution of industrial mineral operations in the United States and some thoughts about the future.

Jan 1, 1999

By Byron V. Knelson

Although the concept of centrifugal recovery has been around in one form or another for many years, it has not been until recent times that it has become clearly understood and properly put into perspective. Simplistic in theory, it is when one begins to examine the variables involved that the true complexities of this matter begin to emerge. In creating an enhanced g force concentrator, there are many aspects both positive and negative that are encountered. Many conditions that are inherent to all conventional 1 g concentrators do not apply to centrifugal concentrators and therefore very few cm factors exist between them. In developing this technology, virtually all principles were proven by method of trial and error. Among the topics discussed are the effect of g force enhancement on particulate behavior with respect to size and shape, density, enrichment, fluidization, and the "teeter principle". In addition, we will discuss the physical effects of g force enhancement with respect to manufacturing in the areas of abrasion, bearings, and vibration. In discussing the recovery parameters of centrifugal concentrators we will draw direct comparisons to various other recovery methods, outlining the conditions most favorable to their application.

Jan 1, 1988

By Rod Heath

The Saskatchewan industry has the advantages of an ore body of a size and consistency unmatched anywhere else in the world, and large, efficient mines with production costs that compare favourably with those in other countries. On the minus side, Saskatchewan is remote from most major markets, and producers face a distribution challenge to reach the offshore markets which is the main focus of this presentation. One of the characteristics of the world potash business is that all of the major sources of production are located in the developed areas of the world, while there is no significant production in any of the highly populated developing countries. The major potash producers are located in Canada and the United States, in West Germany, France, Spain and the U.K., in Russia and East Germany, and in Israel and Jordan. There is currently no significant production in any of the countries in Asia (with the exception of Jordan where a plant is currently in the start-up phase), Africa, Latin America or Oceania, and all of these areas must, therefore, import a11 of their potash requirements from the producing countries.

Jan 1, 1985

One of the largest mining shows in the world is set take place April 15-18 in Santiago, Chile. Expomin 2008 is expected to attract more than 60,000 professionals from around the world who are involved in all aspects of the mining industry. Expomin has become an important place for mining leaders to meet, organizers said, ?with great expectations for the development of new business in international markets.? This is the 10th Expomin. The event, held every two years, is expected to at-tract exhibitors from more than 25 countries, representing nearly 1,000 companies and more than 3,000 brands related to the mining industry, organizers said. Most all of the world?s largest equipment manufacturers and suppliers ? surface and underground ? will be represented. The importance of the event to the Chilean and international mining industry can be seen by the increase in size of the exhibition ? 13 percent more surface space in 2008, compared with the 2006 Expomin. The exhibit will be broken down into four pavilions, covering 34,054 m2 (355,570 sq ft). An outdoor area for the large mining equipment will cover 16,120 m2 (173,520 sq ft).

Jan 1, 2008

By David M. Mchaina, Steve Hardcastle, Michel Grenier

An overview of the process employed to assess arsenic exposure levels at a gold mine is provided together with the recommended control measures. Arsenic and its compounds are regulated in Ontario as designated substances in all workplaces except mines and concentrators. There is a proposal to remove the exemption for mine and concentrators. If the exemption is removed, the mining industry will be required to adopt the proposed exposure Limit of 0.01 mg/m over 40 hours. There are many mines in Ontario which will be affected by this new regulation. To determine the extent of which workers are exposed to Levels exceeding 0.01 mg/m , an assessment program was initiated at the mine. The main objective of the program was to determine the effect of the proposed regulation on underground and surface operations in term of compliance if it becomes Law. The data obtained from the assessment program shared that only 1ML of the workplaces monitored for arsenic indicated levels above the proposed limit of 0.01 ,/yard all workplace levels were below the present Limit of 0.2 mg/m .

Jan 1, 1992

By Thomas D. Kaufmann

The 1982 recession set the US mining and metals industries reeling. Will the oncoming recession of 1991 hit as hard? Probably not, thanks to a shallower downturn, a weaker dollar and remarkable lower costs. Effects of the last recession That the 1982 recession was traumatic to the American mining and metals industry is an understatement. Quantities of metals consumed dropped. Metals prices fell despite continuing general inflation. The resulting real gross revenues of producers of each of the major metals plunged, in the trough of 1982, to levels one-fourth to two-thirds of those of the peak of 1979 (Table 1). By contrast, most industries in the United States were not hit anywhere nearly as hard. Real GNP, the aggregate of all production, slipped only 1 % from 1979 to 1982. Metals are most sensitive to the business cycle because of their applications. All metals but gold are raw materials to downstream industries. Raw materials are victims of strong fluctuations. This is because buying industries try to hold high inventories in boom periods when goods are in short supply. They reduce inventory levels in buyers markets when suppliers have idle capacity and raw materials are in ample supply.

Jan 1, 1990

By Dewa Putu Agus Sudarmaja, Widi Astuti, Januarti Jaya Eka Putri, Yayat Iman Supriyatna, Himawan Tri Bayu Murti Petrus, Siti Nurul Aisyiyah Jenie, Ferian Anggara, Anisa Maulidia, Vincent Sutresno Hadi Sujoto, Sutijan, Wayan Warmada

With the rapid development of renewable energy technology, such as electricity reserves to store energy for electric and battery-electric vehicles, environmentally friendly energy sources are expected to continue to be tapped to meet mobility and stationary energy needs. Lithium is the most attractive candidate for energy storage development. The presence of lithium in the Sidoarjo mud in Indonesia makes it interesting for use as an alternative source of raw material. In this research work, sulfuric acid was used as a solvent, and hydrogen peroxide as an oxidation agent. Lithium recovery was studied with a leaching process at various temperatures (30, 45 and 60 °C) and sulfuric acid concentrations (0.5, 1, 2, 3, 4 and 6 mol/L). Increases in temperature, sulfuric acid concentration and hydrogen peroxide concentration were found to directly affect the lithium recovery. An increase in sulfuric acid concentration is directly proportional to the recovery of lithium in the solution. Optimum conditions were obtained at a sulfuric acid concentration of 6 mol/L and temperature of 60 °C. The shrinking core model was used to study leaching kinetics, and ash layer diffusion acted as a rate-controlling process. The activation energy of the leaching process was found to be 38.90 kJ/mol.

Jun 1, 2024