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By R. D. Dey, V. Castranova, J. M. Antonini, J. A. Blackford Jr.

Alveolar macrophages (AM) exposed to cytokines or bacterial lipopolysaccharide (LPS) produce the free radical nitric oxide (NO·) by an inducible nitric oxide synthase (iNOS). They also release reactive oxygen free radicals following exposure to silica dust. The purpose of the present study was to determine whether NO· is produced by rat AM and/or recruited leukocytes following the intratracheal (IT) instillation of silica. Male Sprague-Dawley rats (175 to 225 g) were IT instilled with either silica dust (10 mg/100 g body wt) or LPS (0.25 mg/100 g body wt). After 24 h, bronchoalveolar lavage cells (BALC) and lavaged lung tissue were assayed for iNOS mRNA. Cell counts of BALC and iNOS-dependent (Nw-nitro-Larginine methyl ester [L-NAME]-inhibitable) chemiluminescence generated by AM were also determined. Northern blot analysis demonstrated that the steady-state levels of BALC iNOS mRNA were significantly increased by 3-fold following IT silica and by 7-fold following IT LPS. Partially enriched fractions of either AM or leukocytes from silica-treated rats both exhibited significantly elevated iNOS mRNA in Northern analysis. iNOS-dependent chemiluminescence was significantly increased in AM by 36-fold following IT silica and by 89-fold following IT LPS. Differential counts of BALC showed that AM numbers did not change in any of the treatments; however, red blood cells increased by 30-fold following IT silica and by 23-fold following IT LPS. Total leukocytes (polymorphonuclear leukocytes plus lymphocytes) increased by 58-fold following IT silica and by 274-fold following IT LPS. The results demonstrate that AM and neutrophils iNOS steady-state mRNA levels, AM iNOS-dependent chemiluminescence, and lavagable red blood cells and leukocytes all increased following IT silica. These findings suggest that NO· production in rat AM and neutrophils is increased in response to silica. NO· has the ability to then combine with superoxide and form a highly reactive toxic species, peroxynitrite, which may be responsible in part for silica-induced lung damage.

Dec 1, 1995

By Clinton C. Knox

The Townsite mine, consisting of 40 acres in the town of Cardin, Okla., is in the center of a highly productive part of the Picher-Cardin district of the Tri-State zinc and lead field. Previous to the time of the work done by the Bureau of Mines, the property had been partly explored by churn drilling, and an area-of about 8 acres in the southwestern corner had been exploited by underground workings. The Bureau of Mines investigation had as its object the more intensive development of the northern part of the property where previous drilling had indicated a possible ore deposit of commercial grade. Churn drilling by the Bureau began in September 1942 and continued to February 1943. Twenty holes totaling 4,827 feet of bore were completed. Utilizing the information gained from these drill holes, the Weidman Mining Co., lessee of the tract, sank a shaft and proceeded to the exploitation of the indicated ore bodies.

Jan 1, 1949

By Wilford S. Wright, Harold E. Heide, Robert L. Thorne, Neal M. Muir, Aner W. Erickson, Bruce I. Thomas

A program of investigation of strategic and critical minerals began in 1940 to examine and develop tungsten occurrences in the western United States and Alaska. During the years in which the nation was at war, this work was given special impetus to stimulate domestic production. This report is a compilation of results of the tungsten investigations in Alaska supplemented by certain data made available by the Territorial Department of Mines and is designed to include in its scope descriptions of all known tungsten occurrences in the Territory. Two areas in Alaska warranted special investigation - one at Gilmore Dome, 16 miles northeast of Fairbanks, and the other in the Hyder District, at the head of Portland Canal. Three tungsten properties - the Stepovich, Colbert, and Yellow Pup - are at Gilmore Dome. The Stepovich property, referred to sometimes as the Cleary Hill tungsten deposit, was worked by the Cleary Hill Mines Co. from April 1942 until May 1944 and was first examined by Robert S. Sanford and Norman Ebbley, Jr., engineers of the Bureau of Mines, in September 1942. The Cleary Hill Mines Co. by that time had explored an 800-foot strike length of the ore zone with 10 bulldozer trenches and was sinking an inclined shaft on ore in the central portion of the explored zone. In January 1943, the senior author, in company with Ebbley and Harry C. Doheny, supervising engineer of R.F.C., examined the property. Preliminary work by the Bureau of Mines began in May 1945, but actual exploration did not commence until late in June and continued until the end of October 1943. The deposit was examined by John B. Mortie, Jr., and William C. Overstreet, of the Federal Geological Survey, in 1942, and this study was continued in 1943 by Frank Byors, who also assisted the Bureau’s engineers on geologic problems. A magnetometer survey of this area was undertaken in 1942 by Henry Joosting and Eskil Anderson, engineers of the Territorial Department of Mines, and was completed with Bureau of Mines assistance in 1943. During 1943 the Bureau completed exploratory projects on the Cleary Hill mine and adjacent Colbert prospect. The field work on the Colbert property was begun early in July 1945 and continued intermittently until the end of October 1943, when it was recessed because of subzero weather. During September 1944, the Bureau of Mines established (by means of a few surface trenches) continuity between the Colbert mineralized zone, high on the dome, and the Yellow Pup vein, the lowest known tungsten mineralization in the area. It is generally recognized that any extensive program to develop the area as a whole logically would be carried out from the lower horizon.

Jun 1, 1948

By B. D. Nash

The Bureau of Mines continued its research into the recovery of fluorine by the phosphoric acid acidulation defluorination of phosphate rock concentrates. A small process development unit with a capacity of about 10 kilo-grams of charge per hour was operated, and concentrates from both Idaho and Florida were processed. Over 80 percent of the fluorine was evolved and recovered as a dilute fluosilicic acid solution. Phosphate extraction from the concentrates always exceeded 98 percent. The fluorine was converted to a synthetic fluorspar product (3CaFa?SiOa) suitable for use as a slag conditioner in electric furnace steelmaking operations.

Jan 1, 1977

By Frank Parrish

THIS REPORT by the Federal Bureau of Mines presents data on water-supply wells used by waterflood operators in North Texas and shows the distribution of permeable source sediments. Averages of well characteristics, including static fluid levels, working fluid levels, net thicknesses, producing rates, and depths, are presented and discussed. Essentially all water used in waterflooding is mineralized water from consolidated sediments. This study is concerned with the geology and distribution of these mineralized source sediments, whereas previous work in this area was predominantly a study of shallow sources of potable water. Tables, isopachous maps, and electric-log cross sections are included to describe the several source aquifers. In general, water-producing capacity increases with depth of the sediments. Wells completed in Cretaceous sediments 82 to 600 feet deep yield 50 to 600 barrels of water daily, whereas those completed in Pennsylvanian sediments 360 to 4,110 feet deep yield 100 to 7,000 barrels daily. Although deeper formations are used where oil and water are produced conjunctively and where large withdrawal rates are required, insufficient well data prevented mapping of deeper formations.

Jan 1, 1961

By Cleo G. Rall

The method for determining the effective porosity of oil- and gas-bearing sands described in this report is a development of earlier methods (28)3/ devised by the Bureau of Mines. The apparatus bas been improved and made more convenient to use, but the procedure is essentially the same as that which has been in use for maw years. A tabulation at the end of the report gives the results of more than 4,800 porosity determinations for oil sands4/ in the fields of 13 States, A selected bibliography of references to articles containing descriptions and evaluations of various methods of' determining porosity is included in this report. The method was devised and developed at the Petroleum Experiment Station at Bartlesville, Okla., as part of the Bureau's research on fluid-energy relationships and on methods of improving the recovery of crude oil from underground reservoirs.

Jan 1, 1954

By R. D. Wilson

Ten to twelve million tons of dust is produced by cement kilns annu-ally in the United States, resulting in a serious waste disposal problem. The Bureau of Mines investigated two alkali volatilization methods for converting this dust into materials for making portland cement and a useful potassium product. Portland cement kiln dust was found to be composed of finely ground cement raw materials (CaC03 and 8i02) having a layer of alkali sulfate (K2S04 and Na2S04). In this form, it cannot be directly recycled to cement kilns because concrete is weakened by a reaction between the alkali and the aggregate. Portland cements with 28-day strengths above 5,000 psi were produced from low-alkali residues using sintering and melting methods. For nearly complete removal of alkalies, primarily potassium sulfate, from cement kiln dust, a temperature above 1,300° C and a reducing atmosphere were required.

Jan 1, 1986

By David A. Monaghan

This report describes the results of a 2-year investigation of extensible face ventilation techniques and systems for use at the working face in underground coal mines. The goal was to provide a safe and convenient method of maintaining the extensible system within 10 feet of the face, thereby ensuring good ventilation. A summary of approximately 20 extensible ventilation systems proposed or tried in the past is included for reference, together with a detailed description of the design, construction, and underground testing of a new extensible brattice panel and a new fiberglass duct system. The extensible brattice system utilized a special panel which could be pushed forward as the miner advanced. Brief testing in three mines revealed some conflict with the mining cycle and led to recommendations for two improved designs. The extensible duct system was designed for a Goodman borer and utilized a telescoping tube on the left side of the roof, so that it could be extended without interfering with the miner operator. For mine sections with right-hand return ventilation, a special flat tube section is used to cross over the entry. Underground testing showed substantial improvement in face ventilation without interfering with production.

Jan 1, 1976

By Donelson A. Robertson

Includes a review of the state-of-the-art of explosives loading in the crushed stone and cement industries of South Florida and the development of a field test program for alternatives. Emphasis is on the loading of small diameter (2 1/4" or less) explosives. Test results ire evaluated for operational and economic feasibility. Details are described of an explosives loading method which involves placing cardboard tubes with external couplings through the hollow drill steel and then Loading explosives into the tube casings after the drill rig has moved off. This method eliminates the hazards peculiar to loading explosives Through the kelly bar. The alternative method can be performed by existing drill rigs with or without minor modification. With modification, improvement in yield per blasthole and/or primary crushing rate provides opportunity so offset some or all of the additional cost.

Jan 1, 1978

By H. A. Dierks, H. B. Link

The purpose of this investigation was to develop a practical feeder apparatus to introduce comparatively large pieces of coal and similar material into a pipeline under pressure in connection with the vertical hydraulic transportation of solids , termed " hydraulic hoisting . " This method of hoisting the precrushed run - of - mine product of an underground mine has been given unusually wide attention abroad and could be of considerable significance to the U.S. mining industry in its search for operating improvements and cost reduction . A lock-hopper assembly was developed after a series of sinking velocity tests were made by dropping anthracite in a column of water . The system functioned reliably as an automatically operated feeder apparatus .

Jan 1, 1964

By T. O. Glover

The Bureau of Mines surveyed unit trainloading and storage installations in the midwestern, eastern, and southeastern coalfields. Nine individual operations were studied in detail as a representative cross section of unit train operations in these areas. Of the nine operations studied, three were in Illinois, two in Kentucky, and one each in West Virginia, Tennessee, Ohio, and Pennsylvania. Information was obtained from coal producers, coal sale agencies, railroads, construction and equipment companies, and power companies.

Jan 1, 1970

By E. G. King

This publication presents original thermal data for a typical variety of perlite and supplies basic information for use in computing energy requirements in processes for expanding perlite. Perlite has been defined by Raiston 4/ as any silicious lava containing dissolved water in sufficient amount to errand into bubbles when the material is quickly heated to a suitable point in the softening range." The uses of expanded perlite in) the construction and ceramic industries have been discussed by Ralston 4/ and King. 5/ The work described here had a dual purpose: (1) It was desired to ascertain quantitatively, using a typical variety of perlite, just how firmly the contained water is held, and (2) it was desired to obtain basic thermal data sufficient for energy-requirement calculations in processes for expanding perlite.

Jan 1, 1948

By Agnes Y. Lee

The Bureau of Mines has developed an effective hydrometallurgical method to recover high-purity Pb metal and elemental S from concentrates. This low-temperature process eliminates S gases and Pb emissions, in contrast to the current high-temperature smelting technology. The method consists of (1) oxidative leaching with H202, Pb02, and waste fluosilicic acid at 95° C to produce a solution of PbSiF6 and a residue containing elemental S, (2) electrowinning the PbSiF6 solution at 35° C to produce 99.99 pct Pb metal and H2SiF6, and (3) solvent extraction to recover S, leaving a residue containing Cu, Ag, and other metal values. Spent electrolyte was recycled repeatedly, with impurity buildup controlled by controlling the leach parameters.

Jan 1, 1986

By William W. Aljoe

The hydrologic characteristics of two abandoned underground coal mine sites, near Latrobe, PA, and Uniontown, PA, were investigated by the U.S. Bureau of Mines for possible implementation of alkaline injection into the mine pools as a means of abating their acid discharges. The Latrobe site was chosen for a one-time application of alkaline injection to achieve a partial, short-term neutralization of a limited portion of the mine pool. A quantity of alkaline reagent (sodium hydroxide) sufficient for a one-time neutralization of the water in this portion of the pool was added. Although nearly all of the neutralizing reagent had moved away from the injection wells within 6 weeks, no evidence of neutralization was noted at the mine discharge during the study period. This lack of neutralization probably occurred because the injection wells did not intercept a primary flow path through the mine. Criteria for successful application of alkaline injection at this or other sites include (1) positive identification of the primary flow paths through the mine pool and (2) addition of quantities of alkaline reagent sufficient to neutralize the entire volume of the pool along the primary flow path.

Jan 1, 2010

By G. E. McElroy

[The ventilation of development faces In nines for diluting Gas or dist concentrations and, in hot nines for providing air-motion cooling effect, by fan-pipe units discharging high-velocity steams of air close to the face, is an important phase of mine ventilation. The effectiveness of such units depends largely on the air-flow distribution between the pipe discharge and the face, n subject on which little definite information is available. A study of the air flow from grills into rooms3/ has provided some basic data, but under conditions so different from mine fan-pipe installations in development ends that the data are of doubtful application to mine installations, owing to differences in air-flow conditions.]

Jan 1, 1940

By J. T. Dunham

Zirconium has possible use in industry where severe corrosion conditions are encountered because it resists attack from a variety of corrosive environments. However, very little experimental testing has been done to evaluate the corrosion behavior of zirconium when simultaneously subjected to high tensile stresses and exposed to corrosive environments. This investigation was initiated for an evaluation test, but was limited to environments consisting of ferric chloride solutions which were known to attack zirconium and were shown to promote stress-corrosion cracking in preliminary tests. Tests for cracking susceptibility were conducted by the Bureau of Mines to show the effect of stress, solution concentration, air aeration of solution, and the method of mechanical processing. Tensile stress was applied to the specimens by a constant-load method which proved more reliable than a constant-strain method.

Jan 1, 1961

By W. H. Eddy

The Bureau of Mines used several laboratory batch flotation schemes combined with magnetic separation to investigate the feasibility of recovering potash feldspar and glass sands from molybdenite tailings. Four molybdenite tailings or prospective tailings were used as test samples. Feldspar concentrates containing from 10.7 pct to 12.0 pct K2O were recovered from three of the four samples. The alkali content of the fourth sample met the grade for a mixed feldspar. All the feldspar concentrates contained iron in excess of the 0.10-pct-Fe203 specification for most uses. Electron-beam microprobe examination of the feldspar concentrates showed the presence of an iron-bearing potash feldspar in quantities that were excessive with respect to most iron specifications. However, a high-quality glass sand was produced from all of the samples.

Jan 1, 1980

By W. P. DYKEMA

This report gins the results of a study conducted hy the Ilnreau of Mines for the purpose of informing the petroleum industry on the recent progress in the de,·elopment nncl application of the absorption process for recO\·ering gasoline from natural gas. The work has been undertaken entirely with regard to plant practice and for the purpose of describing the features and the operation of units of the plants now in use, the improvements that have been made, and the reasons for any ehanges eontemplated by the engineers in eharge· of the plants studied. Throughout the United States the impro,·ements in the absorption process that are under consideration by engineers not only widen practice so as to include gases at all pressures and percentages of gasoline content, but seem to be dewloping definite standards as to dimensions of towers, l"elocities of flow, saturation of oi~ areas of eooling surfaces, and quantities of menstruum to be circulated. Although perfect practice has by no means been attained, the writer belie,·es thnt a description of the current practice at ,·arious plants, including those ob,'iously more efficient features that each plant hns <le\"eloped and uses at one or another stage of treatment, will intere;; t and possibly help all persons operating or designing absorption plants.

Jan 1, 1919

By Walter W. Kaufman

This User&apos;s Manual, extracted from information contained in the Final Report for the above referenced project, outlines test procedures to measure the braking capabilities of underground non-coal rubber-tired mining equipment. Methods to interpret test results, recommendations for safe braking capabilities, and basic techniques to improve braking systems and road surfaces are also discussed. Possible applications for runaway vehicle protective devices other than braking systems are reviewed. Also included is a listing of mining equipment and brake component manufacturers who supply the majority of equipment to the United States non-coal mining industry. In conjunction with this list of manufacturers, a general tabulation of brake related specifications appears for vehicles observed during stopping tests conducted underground.

Jan 1, 1977

By S. L. Weber, V. Castranova, D. E. Banks, J. K. H. Ma, Y. Rojanasakul, J. Y. C. Ma, M. Bhat

"The mechanism of bleomycin-induced pulmonary fibrosis is not ye: clear. Recent studies have shown that alveolar macrophages (AM) can be stimulated by bleomycin in vitro releasing inflammatory cytokines, suggesting that the interaction of bleomycin with AM is an important step in the drug-induced fibrotic process. Bleomycin is known to bind DNA and generate oxygen radicals through complexation with Fe2+ and oxygen. To provide,more insight into the cellular oxidative property of bleomycin, v.s have developed a fluoromicroscopic method using 2',7'-dichlorofluorescin diacetate (DCFHDA) as an oxidative fluorescence probe to study the deomycin-induced intracellular oxidation in rat AM and the inhibition of the oxida¬tion by taurine, a compound known to inhibit the bleomycin-induced fibrosis. Bleomycin at 5 to 20 ug/ml has a moderate stimulatory effect (1.87- to 2.66-fold) on the secretion of superoxide anion. A high concentration of bleomycin (20 ug/ml), however, inhibits cell response to zymosan-induced secretion of superoxide anion. At 4 ug/ml, bleomycin has no effect on cell membrane integrity or morphology but results in a significant increase in intracellular oxidation. This oxidative process is Fe2-,-dependent and is accompanied by an increase in intracellular calcium (35 nM). Both the intracellular oxidation and calcium rise induced by internalized bleomycin are inhibited by pretreatment of cells with varying concentrations of taurine (25, 125, and 187.5 uM). The inhibitory effect on intracellular oxidation .vas found to be 36, 57, and 60%, respectively. These results demonstrate a stimulation-inhibition relationship between bleomycin and taurine on re cellular oxidation at a subcytotoxic dose of bleomycin, suggesting that the oxidative effect of the intracellular bleomycin-Fe2 complex is important in the initiation of the fibrotic process. — Environ Health Perspect 102 (Suppl10):91-96 (1994) IntroductionThe pulmonary system is most susceptible to oxygen radical-induced diseases due to its constant exposure to the highest oxygen tension, and the potential encounters with oxidant gases such as ozone, nitrogen oxides, and toxic doses of dust particles. The lung is also a well-perfused organ and thereby vulnerable to the effect of circulating xenobiotics such as paraquat, and, bleomycin, which is known to cause pulmonary injuries (1). Alveolar macrophages (AM), which act as a means of defense by phagocytizing inhaled dust particles and microorganisms while increasing production of reactive oxidative species, have been shown to play an important role in mechanisms leading to oxidative lung injury and fibrosis (2-4)."

Dec 1, 1995