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By Thomas M. Barczak, Dennis R. Dolinar, Gabriel S. Esterhuizen

Longwall mines typically use some form of standing support for secondary roof support in longwall tailgate entries. Although there have been several new support products developed for this application, there remains no universal design criteria to optimize the application of these support technologies. The requirement for optimization and proper support selection is to understand the degree of control that the support has on the ground behavior. The ground reaction curve and numerical modeling was used to evaluate the impact of standing support on ground behavior. LaModel was used to evaluate the impact of standing support on main roof and floor behavior and pillar yielding. The conclusion drawn from this study was that standing supports do not have sufficient capacity to control main roof or floor loading or prevent the resulting convergence of the tailgate entry. However, it is imperative that this “uncontrollable convergence” be considered in the support design to prevent premature failure of the support. A FLAC model was used to evaluate the near-seam roof and floor behavior in conjunction with the global vertical and horizontal stresses. The model suggests that standing roof supports can have some impact on the ground behavior as the elastic response of the rock is exceeded and rock structure deteriorates from the stress concentrations that develop around the tailgate opening. During this phase, the capacity and stiffness of the standing support can be critical to the stability of the opening, as eventually the rock mass will be transformed into a partially detached structure whose weight must be supported by the standing support. This work is part of a ground control program of research at the National Institute for Occupational Safety and Health (NIOSH) aimed at improving mine safety by reducing roof fall injuries and fatalities.

Coal research and technologic work by the Bureau of Mines covers a broad program of investigation aimed at conservation and utilization of this important natural resource. Conservation is served by a constant search for higher efficiencies in mining, preparation, and use. Increased utilization is sought through various projects that probe new ways to use coal and expand existing coal markets. This report, the twenty-eighth in the series,3 gives the highlights of Bureau of Mines coal research and technologic work in 1963. The scope and complexity of the program makes it virtually impossible to report all progress on every project, even tor a 12-month period. Full insight into each project can be gained only through intensive review of basic objectives, past accomplishments, and current status of the work. Details of the work are given in numerous publications issued by the Bureau and its laboratories and centers located throughout the country.

Jan 1, 1964

Coal research and technologic work by the Bureau of Mines covers a broad program of investigation aimed at conservation and utilization of this important natural resource. Conservation is served by a constant search for higher efficiencies in mining, preparation, and use. Increased utilization is sought through various projects that probe new ways to use coal and expand existing coal markets. This report, the twenty-eighth in the series,3 gives the highlights of Bureau of Mines coal research and technologic work in 1963. The scope and complexity of the program makes it virtually impossible to report all progress on every project, even tor a 12-month period. Full insight into each project can be gained only through intensive review of basic objectives, past accomplishments, and current status of the work. Details of the work are given in numerous publications issued by the Bureau and its laboratories and centers located throughout the country.

Jan 1, 1964

By A. E. Back

[Several processes for recovering manganese from low-grade ores have been proposed3/4/5/ in which an aqueous slurry of the ore is leached with gas containing nitrogen, oxygen, and sulfur dioxide as obtained from burning sulfur or roasting sulfide ores. The manganese dioxide is dissolved, and most of the sulfur dioxide is oxidized to sulfate, but an appreciable quantity of dithionate is usually formed, together with acid from oxidation of the sulfur dioxide. The over-all reactions may be represented as follows: (1) Mn02 + S02 = Mn++ + S04--. (2) Mn02 + 2S02 = Mn++ +S206--. (3) H20 + So2 + 1/2 02 = 2H+ 5S4--. (4) H20 + 2S02 + 1/2 02 = 2H+ + S206---.]

Jan 1, 1952

By N. H. Snyder

THE Bureau of Mines has been active in promoting the purchase of coal for Government use under specifications that define the requirements in terms of heating value of the coal, expressed in British thermal units, and the com-position as shown by proximate analyses. To these, when required, are added the fusing temperature of ash, Hardgrove grindability index, and the free-swelling index. Under most of these specification contracts the bidders guarantee the quality of coal, and that guaranteed by the successful bidder becomes the standard of his contract. The deliveries are sampled in accordance with instructions 4 issued by the Bureau; the samples are analyzed in the Bureau's laboratory to determine whether the coal is of the quality guaranteed by the contractor and, if it is not, a price adjustment is made. Analyses of delivered coal and "tipple" samples (samples collected at mine tipples as coal is being loaded into railroad cars or trucks) are valuable data for use in evaluating future bids. Moreover, the continuous sampling of coal as delivered is a check on the practical results obtained in burning the coal.

Jan 1, 1953

By A. C. Burr

This progress report covers the period from January 1949 to the end of the fiscal year, June 30, 1950. Three runs were successfully completed, and one run was terminated as the result of failure of a cast reaction tube. Including the abbreviated run, the gasifier was operated for 1,915 hours, during which some 428 tons of natural and steam- dried lignite was partly gasified In producing 20 million cubic feet of gas. Gas-production rates varied from 7.8 to 16.4 thousand cubic feet per hour, the latter being the highest production rate yet reached; hydrogen-carbon monoxide ratios of the product gas varied from 1.85, the lowest ratio yet produced, to 6.5; and heat-transfer rates through the heated wall of the outer tube varied from 2,100 to 4,400 B.t.u. per square foot an hour. The general objective of the project is to establish the technology and economy of the gasification of lignite in an externally heated, metal, annular retort. Specific objectives include determination of the useful life of the metal retort tube, which is a continuing problem, and special objectives that were established for each run as part of the systematic investigation of the basic variables of the gasification process. For runs 10 and 11 the special objective was the influence of the lignite feed rate on gasification; for run 12, a comparison of dried and natural lignite, and the production of gas having a hydrogen-carbon monoxide ratio less than 2; and for run 13, the influence of a gradually increasing steam rate with steam admitted to either the upper or lower reaction zones. In addition, during each run the sulfur distribution and concentration in the product gas and char were investigated. Experimental results obtained using the lignite feed rate as the variable indicated that the gas yield per ton of natural lignite varied inversely with the feed rate. Comparison of the gasification of natural and steam-dried Dakota Star lignite indicated that the dried lignite was a superior gasification material because: 1. The hourly gas production was higher at normal combustion space temperatures under nearly equal experimental conditions. 2. On the moisture- and ash-free basis, a considerably higher feed rate could be maintained at a relatively high percentage of carbon gasified. 3. At nearly equal moisture- and ash-free feed rates, the specific gas yield was higher. The location of steam admission was found to be important because the gas yield per ton of natural lignite was higher when at least a portion of' the process steam was admitted to the upper reaction zone. Heat balances showed the potential heat in the gas and char to be 71.8 to 83.6 percent of the total heat input. The sulfur concentration in the product gas was low, being in the range of 35 to 140 grains per 100 cu. ft., of which 1.5 to 2.3 grains was organic sulfur. Careful measurements and inspection of the 310-alloy rolled plate tube following runs 11, 12, and 13 showed no excessive corrosion; however, some radial deformation had occurred indicating that deformation or creep might be the limiting factor in the life of the tube.

Jan 1, 1953

By Gary J. Cwick

Mineral resources of the Rice Valley Wilderness Study Area (WSA), in the Mojave Desert of southeastern California, were investigated by the U.S. Bureau of Mines and U.S. Geological Survey during 1980. The study consisted of an examination of mines, prospects, and mineralized areas by the Bureau: of Mines and geological, geochemical, and geophysical investigations by the Geological Survey. Little indicated potential for the presence of mineral resources exists in the valley floor segment of the study area. The Big Maria Mountains section of the study area has some potential for mineral resource development. Decorative building stone from both bedded quartzite deposits and weathered limestone surface rubble (driftwood stone) has been produced from the Big Maria Mountains segment of the study area. Total production is unrecorded but probably small. A 700,000 ton (640,000 t) quartzite resource was inferred and 4,500 tons (4,100 t) of driftwood stone within the study area was estimated. A relatively pure limestone deposit inside the study area contains an inferred resource of 14 million tons (13 million t). One prospect suggests a potential for the presence of manganese resources although none were estimated. The likelihood of discovering oil, gas, coal, uranium or geothermal energy is low; potential sources are not known to exist.

Jan 1, 1982

By A. F. Baker

Laboratory flotation of synthetic coal-pyrite mixtures and high-pyritic-sulfur coal indicated that ferric chloride (FeCl3), aluminum chloride (AIC13), chromium chloride (CrCl3), and cupric sulfate (CuSO4) are potential pyrite depressants. For each metal salt there appeared to be a range of pH values and optimum concentration for selectively depressing pyrite in coal flotation. Pyrite was depressed in the pH range from 4.5 to 7.0 with ferric chloride, from 5.8 to 7.0 with aluminum chloride, from 6.4 to 7.1 with chromium chloride, and from 6.4 to 7.4 with cupric sulfate. Best separation of pyrite from coal was achieved in flotation solutions containing from 2 X 10-5 to 5 x 10-5 mole/ liter of each salt. In solutions containing excess salt concentrations, coal was also depressed. These Bureau of Mines tests demonstrated on a laboratory scale that, in solutions containing 4 X 10-5 mole/liter ferric chloride and from 1 x 10-4 to 2 x 10-4 mole/liter sodium hydroxide, the pyritic sulfur content of a Lower Freeport bed coal sample could be reduced from about 2.51 percent to less than 0.60 percent with recoveries of over 83 percent. The depression of pyrite appears to be due to the adsorption of positively charged colloidal metal hydroxide at the pyrite-solution interface. This hypothesis is supported by zeta potential determinations which showed that suspended coal and pyrite particles in solutions containing metal salts are positively charged in the pH range where depression occurs.

Jan 1, 1971

By Charles W. Merrill

THE INDUSTRIAL strength and the security of the United States require an adequate, dependable, and continuing supply of raw materials, of which minerals constitute an indispensable segment. With an expanding population, a rising standard of living, and the instability inherent in a constantly changing international situation, the mineral supply outlook is a major national concern. Structures, roads, and machines are built largely of mineral products; the energy to heat the structures and to power the machines is derived mostly from minerals; agricultural out-put is sustained with the aid of mineral fertilizers; and the Nation's economic and military security both are founded ultimately on its ability to obtain and utilize essential metals, nonmetals, and mineral fuels.

Jan 1, 1965

By J. M. Mutmansky

"This study analyzed laboratory comminution techniques for respirable mine dust generation and the properties of the resulting dusts. It was the objective of the study to determine the suitability of the resulting dusts in reflecting the properties of natural airborne dust. This paper deals specifically with the amount of contamination introduced into the generated dust as a result of abrasion when using nine different grinding methods. The analysis was made by comparing the content of 25 chemical elements in the lab-generated dusts with the same elements in the airborne coal mine dusts. It was found that all the lab-generated dusts possessed contamination but that several methods produced smaller percentages of contamination and that the residence time in the grinding device was an important factor in the contamination levels. INTRODUCTIONDust in the atmosphere is a health hazard and a major source of occupational diseases in the coal mining industry (Anon., 1980; Merchant, Boehlecke, and Picket-Hamer, 1986). It has been shown that coal workers' pneumoconiosis (CWP) is directly related to the inhalation and accumulation of respirable coal dust in coal miners' lungs. In order to effectively protect coal workers from coal dusts, we must have a clear understanding of dust properties including dust generation and dust-lung reaction mechanisms. This requires extensive biomedical research. Dust related research often requires large samples of respirable coal dusts to be collected, either for repeated experiments or stored for future reference. Unfortunately, current sampling instruments are not able to meet this demand. Ali a result, laboratory-generated coal dust ls frequently used as a substitute for coal mine dust in biomedical and other research applications. Now, the questions are how close the characteristics of laboratory-generated dusts are to those of mining-generated dusts and which equipment is moat appropriate for research dust production in the laboratory . These are some of the interests of this research project. The primary objective of this project was to find a laboratory technique which can generate coal dusts possessing properties similar to coal mine dust with respect to particle size distribution, chemical composition, and particle shape and morphology. However, this paper will focus only on the chemical compositions of the prepared dust samples and try to identify the sources of chemical contamination from various size reduction processes."

Mar 1, 1992

Research by the National Institute for Occupational Safety and Health (NIOSH) on multiple-seam mining has resulted in two new ground control products. Information Circular (IC) 9495 In some U.S. coalfields, particularly in central Appalachia and the West, most mines are operating above and/or beneath previously mined seams. The effects of multiple-seam interactions can include roof falls, rib spalling, and floor heave. These can seriously threaten the safety of miners and disrupt mining operations. Information Circular (IC) 9495 is a proceedings document containing a variety of papers that summarize recent knowledge about multiple-seam mining. A NIOSH study that analyzed case histories collected from 44 U.S. coal mines is described in detail. The study confirmed that overmining is much more difficult than undermining, and isolated remnant pillars cause more problems than gob-solid boundaries. The study's results were the basis for the Analysis of Multiple-Seam Stability (AMSS) software package. The proceedings also contain two papers describing the LaModel family of software. The original three-dimensional version of LaModel is essential for detailed analyses of complex multiple-seam scenarios. LaM2D implements a simplified, two-dimensional model suitable for quick approximations of the multiple-seam stresses and strains. Three papers in the proceedings focus on case histories. One describes the extensive multiple-seam experience at the Harris No. 1 Mine in West Virginia, a second contains examples of "extreme" multiple-seam mining from the central Appalachian coalfields, and a third describes interactions with regard to longwall mine experiences in Pennsylvania, West Virginia, and Utah. The final paper reports on a numerical modeling study that provided some insight into the mechanics of multiple-seam mining. [ ] AMSS Software Package NIOSH has developed a simple, user-friendly computer program called Analysis of Multiple-Seam Stability (AMSS). AMSS can help mine planners to evaluate each potential multiple-seam interaction and take steps to reduce the risk of ground control failure. AMSS begins by evaluating the pillar design. It first calculates the single-seam pillar stability factor (SF)

Jan 11, 2007

By Steven J. Page, John A. Organiscak

Laboratory crushing experiments were conducted on a range of low- to high-volatile bituminous coals to investigate the various factors influencing airborne respirable dust (ARD) generation. This research was conducted to identify the principles of ARD liberation from the coal product. Five U.S. bituminous coals were uniformly prepared and processed through a double roll crusher located in a low-velocity wind tunnel. Experimental factors studied included inherent coal seam constituents, coal grind ability, specific energy of crushing, product size characteristics, dust cloud electrostatic field, and specific ARD generated. The results of this investigation indicate that a combination of several factors are associated with ARD generation. One factor is the effect of coal rank, described by the inherent moist fuel ratio, on the product size characteristics, defined by Schuhmann size function parameters. Another key factor is the effect of air dry loss(ADL) moisture in the coal seam on the breakage-induced electrostatic field of airborne dust. The effect of these factors is that different percentages of <10-m coal particles are dispersed as ARD. A discussion of electrostatic field principles, coal ADL, and its effect on ARD generation is presented.

Jan 10, 1998

By Richard S. Gaps

The Derby and Alexander Claim, located within the Tunnel Ridge Wilderness Study Area (WSA), has placer gold resources. No lode deposits are known within the area, but lode gold deposits are found within 1 1/2 mi of the WSA. In additon, rock units which contain lode gold deposits north of the WSA are found within the northern portion of the study area. INTRODUCTION The Tunnel Ridge Wilderness Study Area (WSA), CA-030-402, encompasses 4,623 acres of BLM administered public land in Trinity County, California, about 35 mi west-northwest of Redding (fig. 1). Major access to the Tunnel Ridge vicinity is by U.S. Highway 299. Ac-cess to the WSA boundary is by a secondary paved road from Junction City and several light duty dirt and gravel roads (fig. 2). The WSA is on the southwest slope of Weaver Bally Mountain. The topography is rugged with moderate to steep slopes; elevations range from about 1,600 ft to 5,900 ft.

Jan 1, 1983

Background: Frictional ignitions continue to be a problem facing the U.S. underground coal mining industry. Many methane igni-tions are associated with the impact of mining machine cutter bits on quartzitic material (e.g., sandstone) during the coal-cutting process. Most ignitions result in small methane-air fireballs often only a few feet in size and limited to the cutter head location. However, under certain conditions, frictional ignitions can lead to larger methane explosions and/or fires with the potential for causing serious injury or death to the mining machine operator and other nearby miners. The requirements for a frictional ignition are a flammable volume of methane-air and an ignition source. This source is usually the hot streak caused by the frictional impact of the mining bit on hard rock, and the frequency of occurrence increases with increased bit wear. Another possible ignition source is the fric-tional impact of rock on rock during a roof fall.

Mar 1, 2008

By Mark L. Chatman

This report presents an economic mineral assessment and Inventory of mines and prospects In the approximately 176,000-acre Patagonia Mountains-Canelo Hills Unit of Coronado National Forest. Deposits or areas most likely to experience future development are characterized in terms of their economics, based on data acquired by the author from a variety of sources, and supplemented by USBM field data collected by other workers in 1990 and 1991. Numerous mine maps, rock-chip sample assays, and detailed descriptions of mine and prospect sites are in this report and appendixes. Heavy but sporadic mining, mainly between the 1850&apos;s and 1950&apos;s was nearly all confined to the Patagonia Mountains. High-grade sulfide veins, replacements, and skarn deposits accounted for most of the production, which included large quantities of zinc, lead, copper, and silver, and considerable quantities of gold. Small Quantities of molybdenum, manganese, tungsten, and placer gold have been mined. Most of the traditionally mined metalliferous sites will not see future activity due to the low tonnages present and removal of most high-grade rock. Possible future development areas include copper porphyries and breccia pipes; most are too deeply buried for current development. Localities where similar deposits may be concealed are identified.

Jan 1, 1994

By Sean Gallagher, William S. Marras, Alan S. Litsky, Deborah Burr

This paper describes a comparison of the fatigue failure responses of older versus younger lumbar spine cadaver motion segment specimens. These specimens were repeatedly subjected to loads simulating those experienced by the spine in lifting a 9 kg load in different torso flexion postures (0, 22.5, and 45 degrees of flexion). An older sample of 36 motion segments (average age 81 years + 8 SD) is compared with a younger sample of 18 motion segments (average age: 47 years + 9 SD) with respect to the number of cycles to failure and results of survival analyses evaluating the effects of flexion and bone mineral content with and without the younger data set. Compared to the older sample of spines, the younger sample exhibited many more cycles to fatigue failure in all the torso flexion conditions (10020 versus 8267 average cycles to failure in 0 degrees flexion, 7124 versus 3262 in 22.5 degrees flexion, and 3229 versus 263 cycles to failure in 45 degrees flexion). The increased cycles to failure in young specimens is likely due to the increased bone mineral content (BMC) in younger motion segments (30.7 g + 11.1 g per motion segment versus 27.8 + 9.4 g). Cox regression analyses modeling both flexion effects and BMC indicate that betas are similar when just older spines are modeled and when younger specimens are included in the analysis. Betas for survival analysis models with and without younger specimens generally show little change for flexion (2.716 versus 2.756 for 22.5 degrees [0 degrees referent], 3.926 versus 3.380 for 45 degrees [0 degrees referent]). Bone mineral content shows a similar protective effect in both models (Betas: -0.127 versus -0.087). Overall, comparison of the models indicate that risk ratios are similar for 22.5 degrees flexion, slightly increased for 45 degrees flexion and slightly more protective influence predicted for BMC in the combined sample versus the older sample alone.

In the United States water pollution resulting from mining activities has long been recognized as a major environmental problem Mine drainage pollution results from many types of mining activities and includes both physical (i e , sedimentation) and chemical (i e , acidification, metal contamination, etc ) pollutants Active and abandoned surface and underground mines, mineral processing plants, mine and processing plant waste disposal areas, haulage roads, and tailing ponds are typical sources of mine related water pollution (130) One of the most serious pollution problems arising from mining activities is acid mine drainage resulting from the chemical reaction of sulfide minerals (commonly iron sulfides) and air in the presence of water Acid mine drainage is commonly associated with coal and hard rock mining areas in the United States In general the more serious and extensive acid mine drainage problems exist in the more humid coal regions east of the Mississippi River (11) In 1964 the U S Department of the Interior, Fish and Wildlife Service, reported that acid mine drainage adversely affected fish and wildlife habitat in 9,477 kilometers (5,890 miles) of streams and 6,062 hectares (14,967 acres) of impoundments in 20 states in the United States (64) Of the total affected waters, coal mining operations accounted for 97 percent of the acid mine drainage pollution reported for streams and 93 percent of that reported for impoundments In 1970 more than 19,308 kilometers (12,000 miles) of streams in the United States were reportedly significantly degraded by mining related pollution (130) Of the total affected kilometers, 16,920 kilometers (10,516 miles) or approximately 88 percent were located in the Appalachian coal region (Pennsylvania, West Virginia, Ohio, eastern Kentucky, Tennessee, Maryland, and Alabama) In addition, more than 965 kilometers (600 miles) of streams reportedly were degraded by coal mining in states in the Illinois, Western Interior, and Rocky Mountain coal regions The remaining portion of the stream pollution resulted from the mining of (1) copper (california, Montana, Nevada, New Hampshire, Tennessee, Virginia, and Wyoming), (2) lead and zinc (Colorado, Idaho, Kansas, Missouri, Montana, Oklahoma, and Tennessee), (3) uranium (Rocky Mountain States), (4) iron (Lake Superior iron region), (5) sand and gravel (all states), (6) phosphate (Florida and other states), (7) gold (Alaska), (8) bauxite and barite (Arkansas), and (9) molybdenum, gold, and other metals (Colorado) Abandoned mines and abandoned mine waste disposal areas contribute a large portion of the total pollution resulting from mining activities Numerous abandoned underground mines are located throughout the United States and many are discharging mine drainage pollutants In 1966 the U S Bureau of Mines estimated that more than 88,000 inactive and abandoned underground mines were in existance (126) A listing of these mines by state is presented in Table 1 0-1 More recent estimates indicate that this list is incomplete In Colorado alone there is

Jan 1, 1975

By Donald O. Capstick

A mineral resource evaluation of the Coyote-Southeast RARE II area (No. 5033) was performed jointly by the U.S. Bureau of Mines and the U.S. Geological Survey in 1981 for the U.S. Forest Service RARE II program. Bureau of Mines personnel conducted a mineral resource inventory of the study area&apos;s mines, prospects, claims, and mineralized outcrops. The study area&apos;s boundaries encompass 51,700 acres on the east flank of the Sierra Nevada and are within Inyo National Forest southeast of the city of Bishop in east-central California. Cretaceous granite underlies most of the area; the remainder of the rocks are metasedimentary. At the contact of the two, tactites formed at many places where carbonate rocks were present; replacement processes produced local scheelite (calcium tungstate) occurrences.

Jan 1, 1983

By Hisataka Sakakibara

Although the pathophysiology of vibration-induced white finger (VWF) is still under discussion, evidence has been accumulated to understand the underlying mechanism. VWF is pathophysiologically characterized by an enhanced vasospastic response to cold, which can result from an imbalance between vasoconstriction and vasodilation in the digital arteries in response to cold (i.e., vasoconstriction-dominant). The imbalance is supposed to be due to faults in vascular vessels and sympathetically mediated vascular tone. Enhanced vasospastic response to cold Narrowing of arterial lumen with medial smooth muscle hypertrophy. Possible functional factors for enhanced vasoconstriction • Increased sympathetic nervous activity to cold (e.g., norepinephrine) • Increased release of endothelin-1 (ET-1; an endothelial-dependent vasoconstrictor) from the endothelium • Increased reactivity of alpha2-adrenoreceptors to cold Possible functional factors for decreased vasodilation • Decreased release of nitric oxide (NO; an endothelial-dependent vasodilator) from the endothelium • Decreased release of calcitonin gene-related peptide (CGRP; a vasodilatory neuropeptide) from sensory afferents The question is how their interrelations or imbalances among them are Vibration and arterial damage The next question is, how does hand-arm vibration exposure induce such pathophysiological changes in VWF patients? Recent morphological evidence from animal experiments shows that vibration acceleration stress (including shear stress) and smooth muscle contraction contribute to arterial damage of smooth muscle and endothelial cells. The vibration-induced arterial damage is frequency-amplitude-dependent.

Jan 6, 2006

By Claud Johnson, G. Roger Miller, Kristine M. Krajnak, Stacey Waugh, Oliver Wirth

Workers exposed to vibrating hand tools are at risk of developing symptoms such as cold-induced vasospasms, loss of tactile sensitivity, and loss of grip strength in the fingers and hands. These symptoms are known collectively as vibration white finger (VWF) or hand-arm vibration syndrome (HAVS). Symptoms of VWF or HAVS are in part due to repeated and prolonged peripheral vasoconstriction[1, 2]. The reduction in blood flow that occurs with vasoconstriction can result in oxygen deprivation (hypoxia) in soft tissues, such as nerves and muscle, and lead to functional and structural changes in these tissues. The present study examined muscle tissue to determine if vibration-induced changes in transcript levels and protein concentrations result in enhanced vasoconstriction and hypoxia. Manual dexterity was also assessed intermittently to determine if vibration-induced changes in cellular factors are accompanied by performance deficits. Methods An animal model was developed to study the biological and functional changes that occur in response to repeated segmental vibration exposures. In this model, the right paw of intact rats was exposed to a platform vibrated at a frequency 250 Hz and amplitude of 49 m/s2 to simulate the vibration characteristics of hand-held grinders. Three groups of 8 rats each were studied: a vibration-exposed group, an exposure-control group, and a cage-control group. Exposure sessions, with or without vibration, were conducted 4 hr/day, 5 days/week for 5 weeks. Manual dexterity was assessed intermittently during the 5-week exposure period with the Montoya stair-case test[3], which quantifies the rat’s ability to reach for, grasp, and retrieve small food pellets placed below the rat on different levels or steps. Following the 5-week exposure period, the flexor muscles of the right forelimb were collected for analysis of gene expression, protein concentrations, and immunohistochemistry. Results Vibration-exposure resulted in an approximate 2-fold increase in the expression of a2C and a1D receptor transcripts in flexor muscles (Figure 1). These receptors mediate norepinephrine-induced vasoconstriction in smaller arteries. Vibration-exposure also resulted in an approximate 2-fold increase in hypoxia-induced factor-1a (HIF-1a), a transcription factor that is expressed in response to tissue hypoxia. Western analyses demonstrated that restraint caused a decrease in a1-receptor protein concentrations in the flexor, but vibration-exposure prevented the restraint-induced reduction (Figure 2). Immunohistochemistry performed on flexor muscles (not shown) demonstrated that a1 receptors are primarily located in arteries; maintained levels of these receptors could contribute to prolonged vasoconstriction following repeated vibration exposure. The staircase test showed some performance improvement, or a training effect, in manual dexterity for the control groups but not the vibration-exposed group (Figure 3).

Jan 6, 2006